NCT04274283Recruiting
Tessa Jowell BRAIN MATRIX - Platform Study
A British Feasibility Study of Molecular Stratification and Targeted Therapy to Optimize the Clinical Management of Patients With Glioma by Enhancing Clinical Outcomes, Reducing Avoidable Toxicity, Improving Management of Post-operative Residual & Recurrent Disease and Improving Survivorship
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis. A large network of clinical hubs across the United Kingdom, with expertise in managing patients with brain tumours, will be developed. Once established this infrastructure will facilitate the rapid introduction of clinical trials testing targeted therapies tailored to the genetic changes of an individual's tumour.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 14 Feb 2020
- Start date
- 24 Nov 2020
- Primary completion date
- 28 Feb 2027
- Lead sponsor
- University of Birmingham
- Diseases
- Childhood cancers
- NCT number
- NCT04274283
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 24 Nov 2020 to the primary completion date, 28 Feb 2027
- 14 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active treatment of other malignancy
Other
- Primary spinal cord tumours
- Contraindication to MRI
- Patients without standard of care imaging available
Who the study is looking for
- Newly diagnosed suspected WHO Grade 2-4 glioma, (as evidenced radiologically) AND suitable for a diagnostic or therapeutic surgical procedure resulting in a tumour sample matched to a blood sample.
- Patients with progression with known WHO Grade 2-4 glioma (those with available frozen tumour will be prioritised for detailed genomic analysis).
- Valid written informed consent for the study.
Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Terminated |
| Velindre Cancer Centre, Velindre University NHS Trust Coordinator of this site? Confirm its status | Cardiff | United Kingdom | Recruiting |
| NHS Lothian Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Active, not recruiting |
| Queen Elizabeth Unviersity Hospital, NHS Greater Glasgow and Clyde Health Board Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Active, not recruiting |
| St James's University Hospital, Leeds Teaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Leeds | United Kingdom | Recruiting |
| The Walton Centre, The Walton Centre NHS Foundation Trust Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| Charing Cross Hospital, Imperial College Healthcare NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| King's College Hospital, King's College Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| The Christie Hospital, The Christie NHS Foundation Trust Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Recruiting |
| Queen's Medical Centre, Nottingham University Hospitals NHS Trust Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Recruiting |
| Churchill Hospital, Oxford University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Oxford | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.