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NCT04274283Recruiting

Tessa Jowell BRAIN MATRIX - Platform Study

A British Feasibility Study of Molecular Stratification and Targeted Therapy to Optimize the Clinical Management of Patients With Glioma by Enhancing Clinical Outcomes, Reducing Avoidable Toxicity, Improving Management of Post-operative Residual & Recurrent Disease and Improving Survivorship

Source: ClinicalTrials.gov · Last updated 5 May 2026

Brief summary (registry, in English)

The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis. A large network of clinical hubs across the United Kingdom, with expertise in managing patients with brain tumours, will be developed. Once established this infrastructure will facilitate the rapid introduction of clinical trials testing targeted therapies tailored to the genetic changes of an individual's tumour.

Status (registry)
Recruiting
Study type
Observational
Enrollment
1000 (estimated)
First submitted
14 Feb 2020
Start date
24 Nov 2020
Primary completion date
28 Feb 2027
Lead sponsor
University of Birmingham
NCT number
NCT04274283

What you commit to

  • Study type: Observational
  • Planned participants: 1000
  • From 24 Nov 2020 to the primary completion date, 28 Feb 2027
  • 14 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Active treatment of other malignancy

Other

  • Primary spinal cord tumours
  • Contraindication to MRI
  • Patients without standard of care imaging available

Who the study is looking for

  • Newly diagnosed suspected WHO Grade 2-4 glioma, (as evidenced radiologically) AND suitable for a diagnostic or therapeutic surgical procedure resulting in a tumour sample matched to a blood sample.
  • Patients with progression with known WHO Grade 2-4 glioma (those with available frozen tumour will be prioritised for detailed genomic analysis).
  • Valid written informed consent for the study.

Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (14)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
Coordinator of this site? Confirm its status
BirminghamUnited KingdomRecruiting
Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
CambridgeUnited KingdomTerminated
Velindre Cancer Centre, Velindre University NHS Trust
Coordinator of this site? Confirm its status
CardiffUnited KingdomRecruiting
NHS Lothian
Coordinator of this site? Confirm its status
EdinburghUnited KingdomActive, not recruiting
Queen Elizabeth Unviersity Hospital, NHS Greater Glasgow and Clyde Health Board
Coordinator of this site? Confirm its status
GlasgowUnited KingdomActive, not recruiting
St James's University Hospital, Leeds Teaching Hospitals NHS Trust
Coordinator of this site? Confirm its status
LeedsUnited KingdomRecruiting
The Walton Centre, The Walton Centre NHS Foundation Trust
Coordinator of this site? Confirm its status
LiverpoolUnited KingdomRecruiting
Charing Cross Hospital, Imperial College Healthcare NHS Trust
Coordinator of this site? Confirm its status
LondonUnited KingdomRecruiting
King's College Hospital, King's College Hospital NHS Foundation Trust
Coordinator of this site? Confirm its status
LondonUnited KingdomRecruiting
The Christie Hospital, The Christie NHS Foundation Trust
Coordinator of this site? Confirm its status
ManchesterUnited KingdomRecruiting
Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust
Coordinator of this site? Confirm its status
ManchesterUnited KingdomRecruiting
Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
Newcastle upon TyneUnited KingdomRecruiting
Queen's Medical Centre, Nottingham University Hospitals NHS Trust
Coordinator of this site? Confirm its status
NottinghamUnited KingdomRecruiting
Churchill Hospital, Oxford University Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
OxfordUnited KingdomRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.