NCT04274348Completed
Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum
Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum
Source: ClinicalTrials.gov · Last updated 29 Dec 2025
Brief summary (registry, in English)
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Clinical studies have demonstrated a link between staphylococcal skin colonization and the pathogenesis of AD, but the implication of bacterial virulence factors remains largely uncharacterized. Finally, AD is often associated with herpes simplex skin infections. The aim of this project is to investigate the role of staphylococcal toxins in the exacerbation and maintenance of atopic skin inflammation and in the occurrence of infectious complications such as eczema herpeticum.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 41 (actual)
- First submitted
- 14 Feb 2020
- Start date
- 15 Oct 2020
- Primary completion date
- 4 Aug 2025
- Lead sponsor
- Poitiers University Hospital
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT04274348
What you commit to
- Study type: Interventional
- Participants enrolled: 41
- From 15 Oct 2020 to the primary completion date, 4 Aug 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients treated with dermocorticoid or calcineurin inhibitor for less than two weeks
- Patients under systemic treatment : Methotrexate, Ciclosporin, Mycophenolate Mofetil, Azathioprine, general corticosteroids for less than 4 weeks
Age
- Age \< 18 year-old
Other
- Patients with mild AD (SCORAD \< 25)
- Patients without skin lesions in the forearms
- Patients under biological treatment : Dupilumab for less than 5 half-lives
- Patient without Social Security
- Pregnant and nursing women
Who the study is looking for
- Patients with moderate AD (SCORAD between 25 and 50) or severe AD (SCORAD\> 50)
- Skin lesions in the forearms
- Free subject, without neither guardianship, wardship nor subordination
- Patient with Social Security
- Informed and signed consent by the patient after clear and loyal information on the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Unknown status |
| CHU de Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.