Management of Anticoagulant Therapy Monitored by an Implantable Device With Telecardiology in Patients With Acute Coronary Syndrome Associated With de Novo Atrial Fibrillation Arrhythmia

Prior treatment

• Patient already on anticoagulant therapy.
• Contraindications to anticoagulant therapy.
• Active internal hemorrhage, clinically significant bleeding, bleeding non accessible to compression or bleeding diathesis within 30 days prior to selection visit.
• Bleeding event in the twelve months prior to inclusion.
• Elective surgery.
  • Comorbidities :
• Prior history of significant liver disease (acute hepatitis, active chronic hepatitis, cirrhosis) or liver function disorder detected at selection visit.
• Participation in another biomedical research study (interventional or noninterventional) or participation in a research study within the 30 days prior to inclusion.

Other illness

• Atrial fibrillation diagnosed before hospitalization for acute coronary syndrome, whether treated or not.
• Transient atrial fibrillation due to a reversible disorder (thyrotoxycosis, pulmonary embolism, recent surgery).
• Acute coronary syndrome that has not been revascularized.
• Acute coronary syndrome surgically treated (bypass).
• Bleeding events detected either clinically or biologically (hemoglobinemia \< 10g/dl).
• Significant mitral valvular heart disease.
  • General :

Lab values

• Creatinine clearance \< 30 ml per minute.
  • Bleeding risks :
• Platelet count \< 90000/µL at the selection visit.

Other

• Pathologic criteria :
• Atrial fibrillation still present at inclusion time.
• Scheduled aortocoronary bypass.
• Cardiogenic shock.
• Hyperthyroidism.
• Patient under 18.
• Non menopausal woman or without contraception.
• Patient whose physical and / or mental health may have an impact on the compliance to the study.
• Protected adults (under judicial protection, guardianship, or supervision).

• Atrial fibrillation diagnosed before hospitalization for acute coronary syndrome, whether treated or not.
• Atrial fibrillation still present at inclusion time.
• Transient atrial fibrillation due to a reversible disorder (thyrotoxycosis, pulmonary embolism, recent surgery).
• Acute coronary syndrome that has not been revascularized.
• Acute coronary syndrome surgically treated (bypass).
• Patient already on anticoagulant therapy.
• Scheduled aortocoronary bypass.
• Creatinine clearance \< 30 ml per minute.