Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus

Prior treatment

• Not willing to accept surgery or trial protocol;
• Not eligible for surgery;
• Had hysterectomy, chemotherapy, radiotherapy, or hormone therapy before the trail;

Other illness

• With synchronous malignancies or other malignancies than endometrial cancer in 3 years, except for non-melanoma skin cancer;
• With history of important organs transplantation;
• With immune diseases requiring taking immunosuppressants
• With severe mental illness or brain function disorders
• With history of drug abuse;
• Allergic to contrast agent;

Other

• During pregnancy or perinatal period;
• Still participating in other clinical trials;
• Had retroperitoneum lymph node dissection for other reasons.

• Older than 18 years old;
• Clinically diagnosed (by pre-surgical pathology and radiology) as primary endometrial cancer confined to uterus with middle-high risk factors:
  • disease limited to the uterus on image study (MRI, CT or ultrasound);
  • including all histological types of endometrial cancer (endometrioid, serous, clear cell, carcinosarcoma, and undifferentiated carcinoma); not including uterine sarcoma
  • excluding low-risk endometrial cancer (endometrioid G 1-2 with pre-surgical endometrial lesion≤2cm and myometrial invasion \<50%);
  • with one or more middle-high risk factors including: endometrioid endometrial cancer G3, myometrial invasion ≥50%, tumor size≥2cm, type II endometrial cancer, molecular classification of p53abn, LVSI;
  • diagnosis should be confirmed by at least two senior clinicians;
• Be able to undergo staging surgery.