NCT04281329Recruiting
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
Contribution of Left Atrial Epicardial Fat Quantification by Computed Tomography and Left Atrial Strain by MRI in Atrial-Fibrilation Ablation: "The CTStrain-AF Study"
Source: ClinicalTrials.gov · Last updated 6 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Atrial fibrillation ablation (AF) is a standard interventional treatment for patients with symptomatic AF refractory to medical treatment. The known predictive factors for the success of the procedure remain insufficient to predict the probabilities of success and to appropriately select the patients who could benefit the most from this procedure. Left atrium imaging by MRI or CT may be able to identify AF substrate. However data are lacking about the practical impact of these techniques in routine practice to predict AF ablation outcome. The "CT-AF" study is a prospective, interventional, multicenter cohort study. The main objective of this study is to evaluate the prognostic value of a new automated measurement technique for intra-myocardial atrial fat measurement in cardiac CT and the measurement of global left atrial strain in MRI in patients who are candidates for first AF ablation. The main outcome will be the relationship between the relative volume of left atrial fat measured with CT and total left atrial strain in MRI and recurrence of AF at 1 year after the ablation procedure (blanking period of 3 months post ablation excluded).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 130 (estimated)
- First submitted
- 20 Feb 2020
- Start date
- 1 Apr 2022
- Primary completion date
- 1 Apr 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Atrial fibrillation
- NCT number
- NCT04281329
What you commit to
- Study type: Observational
- Planned participants: 130
- From 1 Apr 2022 to the primary completion date, 1 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of an implantable cardiac prosthesis of pacemaker type or defibrillator
- Iodinated / gadolinium contrast medium allergy
Lab values
- Chronic renal failure with clearance \<30ml / min
Other
- Refusal to participate in the study
- Patient who has already benefited from an AF ablation procedure
- Patient for whom an AF ablation procedure by cryoablation system is planned
- Scanner or MRI pre-inclusion not exploitable
- Claustrophobia
- Follow-up visits not possible
- Pregnancy in progress
- Patients unable to sign consent
- Minors and adults protected under legal protection (tutorship or guardianship)
- Period of exclusion from a research study
Who the study is looking for
- Patient in whom radiofrequency AF ablation is scheduled within the next 6 months.
- age ≥18 years
- Patient affiliated to a social security scheme
- Patient informed and given written consent for participation in the study.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier Universitaire Pitie-Salpetriere Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.