NCT04286516Recruiting
Brain Connections for Arm Movement After Stroke
Brain Areas That Control Reaching Movements After Stroke: Task-relevant Connectivity and Movement-synchronized Brain Stimulation
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 76 (estimated)
- First submitted
- 21 Jan 2020
- Start date
- 10 Jan 2020
- Primary completion date
- 1 Sept 2026
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Stroke
- NCT number
- NCT04286516
What you commit to
- Study type: Interventional
- Planned participants: 76
- From 10 Jan 2020 to the primary completion date, 1 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have a serious complicating medical illness that would preclude participation
- Presence of medical condition or implant that prevents safe administration of TMS or MRI
Other
- (for both groups)
- Unable to give informed consent
- Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
- Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
- Unable to comply with requirements of the study
- Enrollment in another greater-than-minimal risk study
- Pregnancy
Who the study is looking for
- Be 45-90 years of age
- Have adequate language and neurocognitive function to participate in training and testing
- Be medically stable to participate in the study
- Be English speaking
- Be 45-90 years of age
- Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
- Stroke onset at least 6 months before enrollment
- Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
- Present with mild to moderate arm dysfunction
- Be medically stable to participate in the study
- Be English speaking
Age in the registry: 45 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
Related publications
- Mapping the Causal Roles of Non-Primary Motor Areas in Human Reach Planning and Execution.Hum Brain Mapp · 2026 · PMID 41641924
This page is information, not medical advice. Discuss any trial with your doctor.