Individualized Brain Stimulation to Improve Mobility in Alzheimer's Disease

Other illness

• A clinical history of stroke, Parkinson's disease or parkinsonian symptoms, multiple sclerosis, normal pressure hydrocephalus, or other neurological conditions outside of mild AD.
• Use of antipsychotics, anti-seizure, benzodiazepines, or other neuroactive medications
• Any report of physician-diagnosis of schizophrenia, bipolar disorder, or other psychiatric illness
• Contraindications to MRI or tDCS, including reported seizure within the past two years, use of neuropsychological-active drugs, the risk of metal objects anywhere in the body, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, pacemakers, etc.), or the presence of any active dermatological condition, such as eczema, on the scalp

Other

• Inability to secure informant participation
• Unwillingness to cooperate or participate in the study protocol
• An inability to ambulate without the assistance of another person (canes or walkers allowed)
• Any report of severe lower-extremity arthritis or physician-diagnosis of peripheral neuropathy
• Severe depression defined by a Center for Epidemiologic Studies Depression scale score greater than 16

• Men and women aged 65 and older living within supportive housing facilities
• Mild Alzheimer's disease (AD) defined by the combination of 1) at least mild cognitive impairment defined as a modified TICS score of ≤ 34, 2) informant-report of Instrumental Activities of Daily Living impairment as defined as a score of ≥ 6 on the NACC Functional Activities Questionnaire, and 3) a Clinical Dementia Rating score of 1.