NCT04290975Completed
Bridging the Childhood Epilepsy Treatment Gap in Africa
Bridging the Childhood Epilepsy Treatment Gap in Africa (BRIDGE)
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
About half of the world's children with epilepsy do not receive treatment - known as the epilepsy treatment gap - with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs). We will conduct the first cluster-randomized clinical trial (cRCT) to determine the efficacy, implementation, and cost-effectiveness of a novel intervention shifting childhood epilepsy care to epilepsy-trained community health extension workers in an effort to close the epilepsy treatment gap. This research will provide information to help extend epilepsy treatment to children in LMICs and worldwide who suffer from untreated seizures.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 1672 (actual)
- First submitted
- 25 Feb 2020
- Start date
- Jun 2020
- Primary completion date
- May 2024
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Epilepsy
- NCT number
- NCT04290975
What you commit to
- Study type: Interventional
- Participants enrolled: 1672
- From Jun 2020 to the primary completion date, May 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Children who have previously been diagnosed with epilepsy and are currently enrolled in other care and treatment, or who have been treated for epilepsy within three months prior to screening
- Children who are currently receiving care by a neurologist or neurosurgeon for a serious brain disorder (e.g., brain tumor, stroke)
Other illness
- Any child who screens positive for epilepsy, has epilepsy upon clinical evaluation, but does not live in Kano, Zaria, and Kaduna, and who is in the judgement of the parents and/or BRIDGE staff to be unable to comply with the study visits because of travel distance from home.
Age
- Lack of informed consent, and/or lack of assent from children \>7 years who are able to provide assent.Inability of the parent or guardian to communicate with healthcare providers in either Hausa or English
Who the study is looking for
- Resident of Kano or Kaduna states and living in the Kano, Zaria, or Kaduna metropolitan areas of northern Nigeria
- Parent or guardian provided informed consent for the screening questionnaire given to the parent/guardian
- Parent or guardian informed consent, plus assent for children \>7 years able to provide assent, for epilepsy diagnostic evaluation if the screening for possible epilepsy is positive
- Diagnosed with possible epilepsy through initial screening, and then diagnosed with epilepsy upon further evaluation by an epilepsy-trained CHW working with the BRIDGE project, who may consult a BRIDGE physician for diagnostic questions
- Parent or guardian provided consent, and assent for children \>7 years able to provide assent, for enrollment in the cRCT of task-shifted epilepsy care versus enhanced physician epilepsy care
Age in the registry: 6 months to 16 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Federal Neuro-Psychiatric Hospital Coordinator of this site? Confirm its status | Kaduna | Nigeria | Unknown status |
| Aminu Kano Teaching Hospital Coordinator of this site? Confirm its status | Kano | Nigeria | Unknown status |
| Ahmadu Bello University Teaching Hospital Coordinator of this site? Confirm its status | Zaria | Nigeria | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.