Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans

Prior treatment

• Taking any medication in the class of antipsychotics

Other illness

• Tested positive for COVID-19 within the past 10 days
• Been in close contact with a COVID-19 positive person within the past 14 days
• Vegan or vegetarian lifestyle or any other dietary restrictions that would interfere with consuming the intervention foods and beverages (including dietary intolerances, allergies and sensitivities)
• Diagnosis of disordered eating or eating disorder
• History of any of the following: Gastric bypass surgery, inflammatory bowel disease (IBD) or other GI conditions that would interfere with consuming the intervention foods, active cancer in the past three years excluding squamous or basal cell carcinomas of the skin that have been handled medically by local excision and other serious medical conditions
• Recent dental work or have conditions of the oral cavity that would interfere with consuming the intervention foods and beverages

Lab values

• LDL cholesterol ≥190 mg/dL
• Triglycerides ≥500 mg/dL
• Recent diagnosis of any of the following or measurement on screening lab tests: Anemia (hemoglobin \<11.7 g/dL) or abnormal liver or thyroid function (defined as liver enzymes that are \>200% of upper limit (ALT upper limit is 43 U/L or Aspartate transaminase (AST) upper limit is 54 U/L) and thyroid function tests: Thyroxine (T4, free) \<0.56 or \>1.64 ng/dL; Thyroid-stimulating hormone (TSH) \<0.35 or \>5.6 μIU/mL).
• Taking any over the counter or prescribed medication for any of the following: Elevated lipids, elevated glucose, high blood pressure, weight loss or conditions that require corticosteroids (e.g. asthma, arthritis or eczema).

Other

• Active participation in another research study
• Blood Pressure (BP): Systolic BP ≥140 mmHg or Diastolic BP ≥90 mmHg
• Current use of smoking or chewing tobacco, e-cigarettes, cigars, vaping, cannabis or other use of nicotine containing products (within the past 6 months)
• Current use of dietary supplements and/or unwillingness to cease intake of dietary supplements
• Unwillingness to consume intervention foods and beverages
• Engage in more than moderate drinking (\> 1 drink serving per day) or binge drinking (4 drinks within two hours).
• Unwillingness to cease alcohol intake as required for specific duration of the study
• Excessive intake of caffeine containing products (excessive defined as ≥ 400 mg/day)
• Unwillingness to refrain from caffeine intake on lab visit days.
• Intentional weight change of ≥5% of body weight within 6 months of entry into the study
• Long term use of antibiotics
• Are pregnant, planning to become pregnant within the duration of the study or breastfeeding.

• Body Mass Index (BMI) 23-39.9 kg/m2 or 32-50% body fat percentage
• Willingness to have blood drawn
• The criteria listed above and at least one of the following: Fasting glucose ≥100 mg/dL but \<126 mg/dL or Fasting triglyceride ≥125 mg/dL or HDL-cholesterol ≤50 mg/dL or Blood Pressure (BP): Systolic BP ≥130 mmHg or Diastolic BP ≥85 mmHg or Hemoglobin A1C ≥ 5.7 and \<6.5%