NCT04293341Completed
Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder
A Comparison of the Efficacy of Transdiagnostic Behavior Therapy and Disorder-specific Therapy in Veterans With PTSD, Anxiety, and Depression
Source: ClinicalTrials.gov · Last updated 6 Nov 2025
Brief summary (registry, in English)
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/anxiety disorders, including posttraumatic stress disorder. The proposed research seeks to evaluate the efficacy of TBT by assessing psychiatric symptomatology and related impairment outcomes in Veterans with depressive/anxiety disorders via a randomized controlled trial of TBT and existing DSTs in Veterans with major depressive disorder, posttraumatic stress disorder, and panic disorder. Assessments will be completed at pre-, mid-, and post-treatment, and at 6-month follow-up. Process variables also will be investigated.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 304 (actual)
- First submitted
- 28 Feb 2020
- Start date
- 1 Oct 2020
- Primary completion date
- 1 Jan 2025
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Depression
- NCT number
- NCT04293341
What you commit to
- Study type: Interventional
- Participants enrolled: 304
- From 1 Oct 2020 to the primary completion date, 1 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- recent history (\< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record or reported during clinical interview
- acute, severe illness or medical condition that likely will require hospitalization and/or otherwise interfere with study procedures as documented in their medical record (e.g., active chemotherapy/radiation treatment for cancer),
- recent start of new psychiatric medication (\< 4 weeks)
- additional comorbid psychiatric diagnoses that were not listed as exclusion criteria are permitted as long as they are considered secondary to the principal diagnosis of MDD, PTSD, or PD/AG as determined by the diagnostic interview
Other
- diagnosis of moderate-to-severe traumatic brain injury in their medical record and/or endorsement of screener questionnaire
- ineligible Veterans will be referred for non-study-related treatments within mental health at the RHJ VAMC
Who the study is looking for
- Participants must be Veterans
- Participants must be clearly competent to provide informed consent for research participation
- Participants must meet DSM-5 criteria for panic disorder, major depressive disorder, or posttraumatic stress disorder
- Participants must be 18-80 years old
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ralph H. Johnson VA Medical Center, Charleston, SC Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.