NCT04294927Recruiting
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
TUBectomy With Delayed Oophorectomy as Alternative for Risk-reducing Salpingo-oophorectomy in High Risk Women to Assess the Safety of Prevention: TUBA-WISP II Study.
Source: ClinicalTrials.gov · Last updated 6 Apr 2026
Brief summary (registry, in English)
The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 3000 (estimated)
- First submitted
- 1 Mar 2020
- Start date
- 1 Mar 2020
- Primary completion date
- 17 Feb 2040
- Lead sponsor
- University Medical Center Nijmegen
- Diseases
- Ovarian cancer
- NCT number
- NCT04294927
What you commit to
- Study type: Interventional
- Planned participants: 3000
- From 1 Mar 2020 to the primary completion date, 17 Feb 2040
- 66 sites in 16 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior bilateral salpingectomy
Other illness
- A personal history of ovarian, fallopian tube or peritoneal cancer
- Current diagnosis or treatment for malignant disease
Other
- Postmenopausal status (natural menopause or due to treatment)
- Wish for second stage RRO within two years after RRS
- Legally incapable
Who the study is looking for
- Women with a class 5 (definitely pathogenic) BRCA1, BRCA2, RAD51C, RAD51D or BRIP1 germline mutation in one of the participating centers.
- Age at inclusion;
- BRCA1: 25-40 years
- BRCA2: 25-45 years
- RAD51C, RAD51D, BRIP1: 25-50 years
- Childbearing completed
- Presence of at least one fallopian tube
- Participants may have a personal history of non-ovarian malignancy
- Informed consent must be obtained and documented according to national and local regulatory requirements and the local rules followed in the institution.
Age in the registry: 25 years to 50 years · Sex: Female · Does not accept healthy volunteers
Sites (66)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Graz Coordinator of this site? Confirm its status | Graz | Austria | Recruiting |
| Royal Adelaide Hospital Coordinator of this site? Confirm its status | Adelaide | Australia | Recruiting |
| The Mater Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Recruiting |
| St Andrew War Memorial Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Recruiting |
| Royal Brisbane Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Recruiting |
| Greenslopes Private Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Recruiting |
| Royal Womens Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Frances Perry House Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Peter MacCallum Centre Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Mercy Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| Monash Health Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| King Edward Memorial Hospital Coordinator of this site? Confirm its status | Perth | Australia | Recruiting |
| Epworth Hospital Coordinator of this site? Confirm its status | Richmon | Australia | Recruiting |
| Western Health Coordinator of this site? Confirm its status | St Albans | Australia | Recruiting |
| Westmead Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| Chris O'Brien Lifehouse Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| Hopital Universitaire Bruxelles Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
| Universitair Ziekenhuis Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Recruiting |
| AC Camargo Cancer Centre Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| Vancouver General Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
| Klinikum St. Marien Amberg Coordinator of this site? Confirm its status | Amberg | Germany | Not yet recruiting |
| Evangelische Waldkrankenhaus Spandau Berlin Coordinator of this site? Confirm its status | Berlin-Spandau | Germany | Recruiting |
| Klinikum Lippe Detmold Coordinator of this site? Confirm its status | Detmold | Germany | Not yet recruiting |
| Evang. Kliniken Essen-Mitte Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
| Vall D'Hebron Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Cork University Hospital Coordinator of this site? Confirm its status | Cork | Ireland | Recruiting |
| Universita di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
| Humanitas San Pio X Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| San Gerardo Hospital Coordinator of this site? Confirm its status | Monza | Italy | Recruiting |
| Gemelli Hospital Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Instituto Nacional de Cancerologia Coordinator of this site? Confirm its status | Mexico City | Mexico | Recruiting |
| Antoni van Leeuwenhoek Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Amsterdam University Medical Center Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Amphia Coordinator of this site? Confirm its status | Breda | Netherlands | Recruiting |
| Catharina Ziekenhuis Coordinator of this site? Confirm its status | Eindhoven | Netherlands | Recruiting |
| Medisch Spectrum Twente Coordinator of this site? Confirm its status | Enschede | Netherlands | Recruiting |
| University Medical Center Groningen Coordinator of this site? Confirm its status | Groningen | Netherlands | Recruiting |
| Medical Center Leeuwarden Coordinator of this site? Confirm its status | Leeuwarden | Netherlands | Recruiting |
| Leiden University Medical Center Coordinator of this site? Confirm its status | Leiden | Netherlands | Recruiting |
| Maastricht University Medical Center Coordinator of this site? Confirm its status | Maastricht | Netherlands | Recruiting |
| Radboudumc Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Recruiting |
| Erasmus Medical Center Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Recruiting |
| Elisabeth-Tweesteden Ziekenhuis Coordinator of this site? Confirm its status | Tilburg | Netherlands | Recruiting |
| University Medical Center Utrecht Coordinator of this site? Confirm its status | Utrecht | Netherlands | Recruiting |
| Maxima Medical Center Coordinator of this site? Confirm its status | Veldhoven | Netherlands | Recruiting |
| Isala Klinieken Coordinator of this site? Confirm its status | Zwolle | Netherlands | Recruiting |
| Akershus University Hospital Coordinator of this site? Confirm its status | Nordbyhagen | Norway | Active, not recruiting |
| Oslo University Hospital Coordinator of this site? Confirm its status | Oslo | Norway | Recruiting |
| Stavanger Uniersity Hospital Coordinator of this site? Confirm its status | Stavanger | Norway | Recruiting |
| Gdynia Oncology Centre Coordinator of this site? Confirm its status | Gdynia | Poland | Recruiting |
| Bonifraterskie Centrum Medyczne Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| Medical University of Silesia Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| National Cancer Institute Warsaw Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| Karolinksa Institutet Coordinator of this site? Confirm its status | Stockholm | Sweden | Recruiting |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| UChicago Medicine Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Duke University Hospital Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
| Harris Health Lyndon B. Johnson Hospital Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| MD Anderson Cancer Centre Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Mount Sinai Hospital Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Hospital of the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| University of Washington Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Washington University Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Hospital Británico Coordinator of this site? Confirm its status | Montevideo | Uruguay | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.