NCT04304651Active, not recruiting
Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism
Screening for Occult Malignancy Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in Patients With Unprovoked Venous Thromboembolism
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
Venous thromboembolism (VTE) can be the earliest sign of cancer. Identifying occult cancers at the time of VTE diagnosis may lead to significant improvement of patients' care. This is also an upmost issue for patients who want to know if an underlying cancer might have triggered the VTE. An individual patient-level data meta-analysis (IPDMA) supports extensive screening strategies for occult cancer especially based on FDG PET/CT, and suggests that the best target population for cancer screening would be patients with unprovoked VTE older than 50 years of age (6.7% in patients aged 50 years or more vs. 1.0% in patients of less than 50 years (OR: 7.1, 95% CI: 3.1 to 16%).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1276 (estimated)
- First submitted
- 7 Mar 2020
- Start date
- 8 Sept 2020
- Primary completion date
- 8 Sept 2026
- Lead sponsor
- University Hospital, Brest
- NCT number
- NCT04304651
What you commit to
- Study type: Interventional
- Planned participants: 1276
- From 8 Sept 2020 to the primary completion date, 8 Sept 2026
- 16 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Hypersensitivity to 18F-FDG or any of the excipients according to the product monograph;
Other
- Patients will be excluded from the study if they have any of the following criteria:
- Refusal or inability to provide informed consent;
- Unavailable to follow-up.
- VTE while on anticoagulation (e.g apixaban, rivaroxaban, edoxaban, dabigatran, warfarin)
Who the study is looking for
- Patients aged 50 years or older with a new diagnosis of first unprovoked proximal deep vein thrombosis (DVT) and/or pulmonary embolism (PE) will be eligible to participate into the study.
- Unprovoked VTE is defined as the absence of any of the following predisposing factors:
- active malignancy (known malignancy, progressive and/or treated during the last 5 years) except for adequately treated basal or squamous cell carcinoma; Patients whose state of health suggests the presence of cancer at the time of diagnosis of VTE cannot be included in the protocol
- recent (less than 3 months) paralysis, paresis or plaster immobilization of the lower extremities;
- recently bedridden for period of 3 or more days, or major surgery, within the previous 12 weeks requiring general or regional anaesthesia;
- previous unprovoked VTE;
- known thrombophilia (hereditary or acquired)
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (16)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Jewish General Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Ottawa Hospital Research Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Hopital Montfort Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Sherbrooke Hospital Coordinator of this site? Confirm its status | Sherbrooke | Canada | Unknown status |
| University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Sunnybrook Research Institute Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| CH Agen Coordinator of this site? Confirm its status | Agen | France | Unknown status |
| CHU Angers Coordinator of this site? Confirm its status | Angers | France | Unknown status |
| Brest University Hospital Coordinator of this site? Confirm its status | Brest | France | Unknown status |
| CHU de Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Unknown status |
| CHU de DIJON Coordinator of this site? Confirm its status | Dijon | France | Unknown status |
| CHU de Limoges Coordinator of this site? Confirm its status | Limoges | France | Unknown status |
| CH des Pays de Morlaix Coordinator of this site? Confirm its status | Morlaix | France | Unknown status |
| Hôpital Européen Georges Pompidou Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| CHU Saint-Etienne Coordinator of this site? Confirm its status | Saint-Etienne | France | Unknown status |
| Hôpital Saint Musse - CH Toulon Coordinator of this site? Confirm its status | Toulon | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.