NCT04315324Active, not recruitingPhase 1/2
Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)
A Phase I/II Study of AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/T-Cell Lymphoblastic Lymphoma (T-LBL)
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
This phase I/II trial studies the safety, side effects and best dose of OBI-3424 and how well it works in treating patients with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Chemotherapy drugs, such as OBI-3424, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. OBI-3424 may reduce the amount of leukemia in the body.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 67 (estimated)
- First submitted
- 18 Mar 2020
- Start date
- 8 Feb 2021
- Primary completion date
- 28 Oct 2025
- Lead sponsor
- SWOG Cancer Research Network
- NCT number
- NCT04315324
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 67
- From 8 Feb 2021 to the primary completion date, 28 Oct 2025
- 163 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patients must have a diagnosis of relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) based on World Health Organization (WHO) classification. Patients with relapsed/refractory T-cell lymphoblastic lymphoma are eligible if lymphoblasts are \>= 5% in the bone marrow or in the peripheral blood by morphology or flow cytometry
- Patients must have evidence of acute leukemia in their peripheral blood or bone marrow. Patients must have \>= 5% lymphoblasts in the peripheral blood or bone marrow within 14 days prior to registration. Patients with only extramedullary disease are not eligible
- Patients ≥ 18 years of age must be refractory to or have relapsed following a standard induction chemotherapy. Patients \< 18 years of age must have relapsed or must be refractory after 2 or more chemotherapy cycles (example: induction and consolidation)
- A standard chemotherapy induction regimen is defined as any program of treatment that includes:
- Vincristine and corticosteroids plus at least one more chemotherapy agent
- Cytarabine and anthracycline, or
- High dose cytarabine (defined as at least 1 gr/m\^2 per individual dose unless adjustments were required for renal/liver function)
- Patients must have no evidence of central nervous system disease within 28 days prior to registration based on cerebrospinal fluid (CSF) studies. Patients with clinical signs or symptoms consistent with central nervous system (CNS) involvement must have a lumbar puncture which is negative for CNS involvement; the lumbar puncture must be completed within 28 days prior to registration. Patients with CNS1 or CNS2 are eligible; however patients with CNS3 are not eligible
- Note that the patients may receive intrathecal chemotherapy with the initial lumbar puncture. This may count as the first dose of intrathecal therapy required as part of the study
- Prior nelarabine therapy is not required. In addition, for patients ≥ 18 years of age who received nelarabine during initial induction or post-remission treatment are eligible only if the physician does not feel they would benefit from other, multi-agent chemotherapy
- Patients must not have had chemotherapy or investigational agents within 14 days prior to registration except for corticosteroids, oral 6-mercaptopurine, oral methotrexate, vincristine, intrathecal chemotherapy, or hydroxyurea. For participants who have received radiation therapy, at least 7 days must have elapsed from the end of radiation prior to registration and participants must not currently be experiencing toxicities from radiation therapy
- Patients must not have undergone allogeneic hematopoietic transplant within 90 days prior to registration
- Patients must have no evidence of active \>= grade 2 acute graft versus host disease (GVHD) or moderate or severe limited chronic GVHD. Patients must have no history of extensive GVHD of any severity within 90 days prior to registration. Patients who are post-transplant must be off calcineurin inhibitors for at least 21 days to be eligible. Extensive GVHD is defined as 1) generalized skin involvement or 2) localized skin involvement and/or hepatic dysfunction plus liver histology or cirrhosis or involvement of eye or minor salivary organ or oral mucosa or any other target organ
- Patients must be \>= 12 years of age
- Patients ≥ 16 years of age must have a Zubrod Performance Status of 0-3. Patients \< 16 years of age must have a Lansky score of ≥ 50
- Patients must not have systemic fungal, bacterial, viral or other infection that is not controlled (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite appropriate antibiotics or other treatment) within 14 days prior to registration
- Patients ≥ 18 years of age must have creatinine clearance \> 30 mL/min within 14 days prior to registration according to the Cockcroft Gault equation
- Patients 12-17 years of age must have adequate renal function within 14 days prior to registration defined as serum creatinine ≤ 1.5 x institutional upper limit of normal (ULN) according to age or a calculated estimated glomerular filtration rate (eGFR) (based on Schwartz formula) or radioisotope glomerular filtration rate (GFR) ≥ 50ml/min/1.73 m\^2
- Patients must have direct bilirubin =\< 1.5 x institutional upper limit of normal (ULN) within 14 days prior to registration
- Patients must have alanine aminotransferase (ALT) =\< 3.0 x institutional upper limit of normal (ULN) or =\< 5.0 x ULN (if thought to be related to leukemic involvement) within 14 days prior to registration
- Prothrombin time (PT)/partial thromboplastin time (PTT)/ fibrinogen (as clinically indicated for example but not limited to history of bleeding or active bleeding, concern for disseminated intravascular coagulation) (within 14 days prior to registration to obtain baseline measurements)
- From metabolic panel (comprehensive or basic): sodium, potassium, chloride, carbon dioxide (CO2), and blood urea nitrogen (BUN) (within 14 days prior to registration to obtain baseline measurements)
- Patients must be able to safely discontinue use of strong inhibitors/inducers of CYP3A4 or PgP-g-p and must be able to safely discontinue use of naproxen for 48 hours before and after each dose of OBI-3424
- Patients with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test within 6 months prior to registration. (HIV viral load testing is required only for patients with known HIV infection). Patients must not be receiving antiviral therapies that are known strong inhibitors or inducers of CYP3A4
- Patients with evidence of chronic hepatitis B virus (HBV) infection may be eligible provided that they have an undetectable HBV viral load within 28 days prior to registration. Patients may be currently receiving HBV treatment. (HBV viral load testing is required only for patients with known HBV infection). Patients must not be receiving antiviral therapies that are known strong inhibitors or inducers of CYP3A4
- Patients with known history of hepatitis C virus (HCV) infection may be eligible provided that they have an undetectable HCV viral load within in 28 days prior to registration. Patients may be currently receiving treatment. (HCV viral load testing is required only for patients with known HCV infection). Patients must not be receiving antiviral therapies that are known strong inhibitors or inducers of CYP3A4
- Patients must not have a known history of prolonged QT interval by Fridericia (QTcF) (interval \> 450 msec for males; \> 470 msec for females). Patients that had transient prolongation of QTc secondary to medications or electrolyte abnormalities are not excluded if the QTc normalized and remain within acceptable QTcF range (interval \> 450 msec for males; \> 470 msec for females). Additionally, suspected medications should be no longer required or used, and electrolyte abnormalities must have normalized
- Patients must not be pregnant or nursing due to the teratogenic potential of the drug used on this study. Females of reproductive potential must have a negative serum pregnancy test within 14 days prior to registration. Women/men of reproductive potential must have agreed to use an effective contraceptive method during and up to 6 months after treatment. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
- Patients must not have other active malignancies for which they have received treatments within 6 months prior to registration excluding localized malignancies that do not require systemic treatment
- Patients must agree to have bone marrow and blood specimens submitted for MRD testing
- Patients must be offered the opportunity to participate in specimen banking. With patient consent, residuals from specimens submitted will be retained and banked for future research
- Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with fedral, local, institutional and Central Institutional Review Board (CIRB) guidelines unless they are unable to provide consent based on age (\< 18 years) or based on impaired decision-making capabilities. For patients \< 18 years of age or with impaired decision making capabilities, parents or other legally authorized representatives must sign and give informed consent on behalf of study participants in accordance with applicable federal, local, institutional and CIRB regulations
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- This trial will use a slot reservation system to enroll the Phase I portion of the study. Patients planning to enroll at this phase of the study must first have a slot reserved in advance of the registration. All site staff will use OPEN to create a slot reservation
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (163)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| PCR Oncology Coordinator of this site? Confirm its status | Arroyo Grande | United States | Unknown status |
| Children's Healthcare of Atlanta - Arthur M Blank Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Emory University Hospital/Winship Cancer Institute Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Augusta University Medical Center Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| Children's Hospital Colorado Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Dell Children's Medical Center of Central Texas Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Johns Hopkins University/Sidney Kimmel Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| LSU Health Baton Rouge-North Clinic Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Our Lady of the Lake Physician Group Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Bronson Battle Creek Coordinator of this site? Confirm its status | Battle Creek | United States | Unknown status |
| Overlake Medical Center Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| University of Alabama at Birmingham Cancer Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Unknown status |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Fairview Ridges Hospital Coordinator of this site? Confirm its status | Burnsville | United States | Unknown status |
| Minnesota Oncology - Burnsville Coordinator of this site? Confirm its status | Burnsville | United States | Unknown status |
| Loyola Center for Health at Burr Ridge Coordinator of this site? Confirm its status | Burr Ridge | United States | Unknown status |
| Cambridge Medical Center Coordinator of this site? Confirm its status | Cambridge | United States | Unknown status |
| Carson Tahoe Regional Medical Center Coordinator of this site? Confirm its status | Carson City | United States | Unknown status |
| University of Virginia Cancer Center Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| University of Illinois Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Chicago Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Lurie Children's Hospital-Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Cincinnati Children's Hospital Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| University of Cincinnati Cancer Center-UC Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Cleveland Clinic Foundation Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Prisma Health Richland Hospital Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| Wayne State University/Karmanos Cancer Institute Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| City of Hope Comprehensive Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Unknown status |
| El Paso Children's Hospital Coordinator of this site? Confirm its status | El Paso | United States | Unknown status |
| Weisberg Cancer Treatment Center Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| Golisano Children's Hospital of Southwest Florida Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Unity Hospital Coordinator of this site? Confirm its status | Fridley | United States | Unknown status |
| Trinity Health Grand Rapids Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Las Vegas Urology - Pebble Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Las Vegas Cancer Center-Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Urology Specialists of Nevada - Green Valley Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| OptumCare Cancer Care at Seven Hills Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| GenesisCare USA - Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Las Vegas Urology - Green Valley Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Cancer and Blood Specialists-Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital Coordinator of this site? Confirm its status | Hollywood | United States | Unknown status |
| Loyola Medicine Homer Glen Coordinator of this site? Confirm its status | Homer Glen | United States | Unknown status |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| West Michigan Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Bronson Methodist Hospital Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Beacon Kalamazoo Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Beacon Kalamazoo Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Children's Mercy Hospitals and Clinics Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Kingman Regional Medical Center Coordinator of this site? Confirm its status | Kingman | United States | Unknown status |
| Gundersen Lutheran Medical Center Coordinator of this site? Confirm its status | La Crosse | United States | Unknown status |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| Las Vegas Urology - Smoke Ranch Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Radiation Oncology Centers of Nevada Central Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada-Summerlin Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Central Valley Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Las Vegas Prostate Cancer Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Las Vegas Urology - Sunset Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Urology Specialists of Nevada - Southwest Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| GenesisCare USA - Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at Charleston Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Urology Specialists of Nevada - Northwest Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at MountainView Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Town Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Las Vegas Cancer Center-Medical Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Northwest Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Hope Cancer Care of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| GenesisCare USA - Vegas Tenaya Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| GenesisCare USA - Las Vegas Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Ann M Wierman MD LTD Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| University Medical Center of Southern Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Radiation Oncology Centers of Nevada Southeast Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Urology Specialists of Nevada - Central Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Sunrise Hospital and Medical Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Las Vegas Urology - Cathedral Rock Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| HealthCare Partners Medical Group Oncology/Hematology-Tenaya Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Summerlin Hospital Medical Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| University Cancer Center Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Las Vegas Urology - Pecos Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| HealthCare Partners Medical Group Oncology/Hematology-San Martin Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Desert West Surgery Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Arkansas Children's Hospital Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| Loma Linda University Medical Center Coordinator of this site? Confirm its status | Loma Linda | United States | Unknown status |
| Norton Children's Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Fairview Clinics and Surgery Center Maple Grove Coordinator of this site? Confirm its status | Maple Grove | United States | Unknown status |
| Minnesota Oncology Hematology PA-Maplewood Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Saint John's Hospital - Healtheast Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Unknown status |
| Loyola University Medical Center Coordinator of this site? Confirm its status | Maywood | United States | Unknown status |
| Marjorie Weinberg Cancer Center at Loyola-Gottlieb Coordinator of this site? Confirm its status | Melrose Park | United States | Unknown status |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Hennepin County Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| University of Minnesota/Masonic Cancer Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Health Partners Inc Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Monticello Cancer Center Coordinator of this site? Confirm its status | Monticello | United States | Unknown status |
| West Virginia University Healthcare Coordinator of this site? Confirm its status | Morgantown | United States | Unknown status |
| Trinity Health Muskegon Hospital Coordinator of this site? Confirm its status | Muskegon | United States | Unknown status |
| The Children's Hospital at TriStar Centennial Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| UC Comprehensive Cancer Center at Silver Cross Coordinator of this site? Confirm its status | New Lenox | United States | Unknown status |
| Cancer Center of Western Wisconsin Coordinator of this site? Confirm its status | New Richmond | United States | Unknown status |
| New Ulm Medical Center Coordinator of this site? Confirm its status | New Ulm | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Niles Hospital Coordinator of this site? Confirm its status | Niles | United States | Unknown status |
| Children's Hospital of The King's Daughters Coordinator of this site? Confirm its status | Norfolk | United States | Unknown status |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Coordinator of this site? Confirm its status | Norton Shores | United States | Unknown status |
| Children's Hospital and Medical Center of Omaha Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Children's Hospital of Orange County Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| University of Chicago Medicine-Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Unknown status |
| Hope Cancer Care of Nevada-Pahrump Coordinator of this site? Confirm its status | Pahrump | United States | Unknown status |
| Children's Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Children's Hospital of Pittsburgh of UPMC Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Oregon Health and Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Fairview Northland Medical Center Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Rhode Island Hospital Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
| Corewell Health Reed City Hospital Coordinator of this site? Confirm its status | Reed City | United States | Unknown status |
| Saint Mary's Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Renown Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Radiation Oncology Associates Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Valley Medical Center Coordinator of this site? Confirm its status | Renton | United States | Unknown status |
| VCU Massey Comprehensive Cancer Center Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| North Memorial Medical Health Center Coordinator of this site? Confirm its status | Robbinsdale | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Huntsman Cancer Institute/University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Methodist Children's Hospital of South Texas Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| University of Texas Health Science Center at San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Fred Hutchinson Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| University of Washington Medical Center - Montlake Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Saint Francis Regional Medical Center Coordinator of this site? Confirm its status | Shakopee | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Lakeview Hospital Coordinator of this site? Confirm its status | Stillwater | United States | Unknown status |
| Johns Hopkins All Children's Hospital Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Munson Medical Center Coordinator of this site? Confirm its status | Traverse City | United States | Unknown status |
| Ridgeview Medical Center Coordinator of this site? Confirm its status | Waconia | United States | Unknown status |
| University of Cincinnati Cancer Center-West Chester Coordinator of this site? Confirm its status | West Chester | United States | Unknown status |
| Rice Memorial Hospital Coordinator of this site? Confirm its status | Willmar | United States | Unknown status |
| Alfred I duPont Hospital for Children Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
| Minnesota Oncology Hematology PA-Woodbury Coordinator of this site? Confirm its status | Woodbury | United States | Unknown status |
| Fairview Lakes Medical Center Coordinator of this site? Confirm its status | Wyoming | United States | Unknown status |
| University of Michigan Health - West Coordinator of this site? Confirm its status | Wyoming | United States | Unknown status |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Coordinator of this site? Confirm its status | Yakima | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.