NCT04318977Active, not recruiting
rTMS Add on Value for Amelioration of Negative Symptoms of Schizophrenia
Source: ClinicalTrials.gov · Last updated 19 Sept 2025
Brief summary (registry, in English)
Treatment of depression with repetitive transcranial magnetic stimulation (rTMS) has shown high evidence using high-frequency left dorsolateral prefrontal cortex (DLPFC) stimulation. The treatment of negative symptoms with the same protocol in schizophrenia is considered as possible effective. Theta burst stimulation is a new protocol which is characterized by shorter sessions showing first evidence that it's efficacy is comparable to the high-frequency rTMS. In this randomized placebo-controlled study the efficacy of high-frequency rTMS and TBS are evaluated.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 62 (actual)
- First submitted
- 16 Mar 2020
- Start date
- Feb 2020
- Primary completion date
- Aug 2024
- Lead sponsor
- University of Regensburg
- Diseases
- Schizophrenia
- NCT number
- NCT04318977
What you commit to
- Study type: Interventional
- Participants enrolled: 62
- From Feb 2020 to the primary completion date, Aug 2024
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- clinically relevant unstable concomitant somatic diseases
- previous treatment by rTMS
- unacceptable concomitant medication (benzodiazepines in higher doses, e.g., Lorazepam \> 2 mg/d, Diazepam \> 10 mg/d)
Other illness
- conditions in which TMS may not be applicated, as e.g., cardiac pacemakers or ferromagnetic implants
- history of epileptic seizures
Other
- current substance or alcohol abuse, or clinically relevant comorbidity (according to M.I.N.I. interview)
- insufficient knowledge of the language of the country of the treatment site
- pregnancy and nursing period
- current statutory hospitalisation
Who the study is looking for
- ICD-10: schizophrenia with primarily negative symptoms
- Age: 18-75 years
- at least 35 Points at the composite score of the SANS
- stabe medication during the last 2 weeks (at the investigator's discretion)
- written informed consent (by the patient or guardian)
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brno University Hospital Coordinator of this site? Confirm its status | Brno | Czechia | Unknown status |
| University Hospital Ostrava Coordinator of this site? Confirm its status | Ostrava | Czechia | Unknown status |
| University Hospital Aachen Coordinator of this site? Confirm its status | Aachen | Germany | Unknown status |
| University of Regensburg Coordinator of this site? Confirm its status | Regensburg | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.