NCT04319068Active, not recruiting
Sodium Storage in Singaporeans
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
The overarching hypothesis of this study is that the kidney and the skin form an integrative network for water conservation, where Na+ storage is utilized to prevent body water loss, even at the expense of increased cardiovascular risk. The aim of this project is to characterise skin and muscle Na+ storage in a cohort designed to prospectively measure cardiovascular outcomes in Singaporeans, in order to determine whether humans with increased tissue Na+ storage have increased cardiovascular risk. To gain a better understanding of the mechanisms behind Na+ storage, the investigators will also test the hypothesis that participants with mutations of the skin protein filaggrin, who have increased water loss through the skin, will have increased skin Na+ storage and higher blood pressure levels.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 600 (estimated)
- First submitted
- 18 Mar 2020
- Start date
- 2 Jul 2019
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Jens Titze
- Diseases
- High blood pressure
- NCT number
- NCT04319068
What you commit to
- Study type: Observational
- Planned participants: 600
- From 2 Jul 2019 to the primary completion date, 31 Dec 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have received an organ or bone marrow transplant
- Patients who have had major surgery in the past 3 months
Other illness
- Patients with exclusion criteria for the MRI, such as:
- implanted devices (surgical clips, heart pacemakers or defibrillators, cochlear implants)
- iron-based tattoos
- any other pieces of metal or devices that are not MR-Safe anywhere in the body
- patients who exhibit noticeable anxiety and/or claustrophobia into the MRI scanner
- Diagnosis of heart failure NYHA classes III and IV
- Liver disease with cirrhosis (Child-Pugh class C) or hypoalbuminemia
- Active cancer
- Patients who have severe comorbid conditions likely to compromise survival or study participation
Lab values
- Impaired renal function with eGFR\<45 ml/min or proteinuria \> 0.5 g/24h
Other
- Pregnant women
- Peripheral oedema as assessed by the investigator
- Unwillingness or other inability to cooperate
Who the study is looking for
- Participants from the Biobank (Molecular and Imaging Studies of Cardiovascular Health and Disease) cohort in Singapore, who agreed to be contacted for further studies
- Male and female patients older than 21 years
- Willingness to participate and ability to provide informed consent
Age in the registry: 21 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Heart Centre Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Duke NUS Medical School Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.