NCT04319328Completed
Is Cefazolin, Ceftazidime and Ciprofloxacin Dosing Optimal in Hemodialysis Patients?
Pharmacokinetic Evaluation of Cefazolin, Ceftazidime, and Ciprofloxacin in Chronic Hemodialysis Patients
Source: ClinicalTrials.gov · Last updated 16 May 2024
Brief summary (registry, in English)
This study aims to optimize the dosing of cefazolin, ceftazidime, and ciprofloxacin for patients on high-flux hemodialysis. For each antibiotic 20 participants will be enrolled and three blood samples will be collected from each participant. Antibiotic levels will be measured in each blood sample. This data will be used to develop population-pharmacokinetic models for each antibiotic. Finally, Monte Carlo simulations will be used to develop evidence-based dosing recommendations.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 40 (actual)
- First submitted
- 2 Mar 2020
- Start date
- 18 Oct 2019
- Primary completion date
- 30 Apr 2024
- Lead sponsor
- University of Manitoba
- Diseases
- Chronic kidney disease
- NCT number
- NCT04319328
What you commit to
- Study type: Observational
- Participants enrolled: 40
- From 18 Oct 2019 to the primary completion date, 30 Apr 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received study drug as part of a different treatment course in 1-week preceding start of new treatment course
Other illness
- Chronic liver disease, Child Pugh Class C or higher
Other
- Acute kidney injury or recovering kidney function
Who the study is looking for
- \>18 years old
- Proven or suspected infection
- Receiving cefazolin, ceftazidime, or ciprofloxacin for treatment
- Treatment course allows for collection of three 6 mL blood samples as per protocol
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Saint Boniface Hospital, Outpatient Hemodialysis Unit Coordinator of this site? Confirm its status | Winnipeg | Canada | Unknown status |
| College of Pharmacy, University of Manitoba Coordinator of this site? Confirm its status | Winnipeg | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.