NCT04320264Recruiting
Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
Source: ClinicalTrials.gov · Last updated 7 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 3 Sept 2019
- Start date
- 3 Mar 2020
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- East Carolina University
- Diseases
- Obesity
- NCT number
- NCT04320264
What you commit to
- Study type: Observational
- Planned participants: 100
- From 3 Mar 2020 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have had weight fluctuations exceeding + 3% in the previous 12 months
- On medications which alter carbohydrate metabolism will not be studied
Other illness
- Subjects with heart disease
- Type 1 and 2 diabetes
- Endocrine disease
- Hypertension
- Musculoskeletal disease
- Hepatic disease
Other
- Pregnant women
- Mentally disabled
- Prisoners
- Smokers
- Peripheral occlusion
Who the study is looking for
- 18-50 years old
- BMI of 25 - 30 kg/m2
- BMI \> 40kg/m2
- Lactate levels in top and lower 25%
Age in the registry: 18 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| East Carolina University Coordinator of this site? Confirm its status | Greenville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.