NCT04328337CompletedPhase 1/2
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
Source: ClinicalTrials.gov · Last updated 2 Nov 2026
Brief summary (registry, in English)
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 27 Mar 2020
- Start date
- 8 Dec 2020
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Obesity
- NCT number
- NCT04328337
What you commit to
- Study type: Interventional · Phase 1/2
- Participants enrolled: 40
- From 8 Dec 2020 to the primary completion date, 1 Jun 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of any medications, vitamins, or supplements that can alter cerebral metabolism or lipids
- Current or recent steroid use in last 6 months
- Illicit drug use/alcoholism
Other illness
- Known hepatic, gastrointestinal, renal, neurologic, psychiatric, cerebrovascular disease
- Uncontrolled hypertension
Lab values
- Creatinine \>1.5mg/dL
- ALT and AST \>2.5X upper limit of normal
- Abnormal PT/PTT/INR
- Triglycerides \>200 mg/dL
Other
- Hematocrit \<35% for females and \<39% for males
- Abnormal TSH
- Current or past 3 months use of ketogenic diet
- Smoking
- \>5% body weight change in last 6 months
- Inability to enter MRI/MRS
- For women: pregnancy, seeking pregnancy, or breastfeeding
Who the study is looking for
- Age 18-45 years
- HbA1C \<6.5%
- Normal weight individuals: BMI 17-25 kg/m\^2
- Obese individuals: BMI \>30 kg/m\^2
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Biomedical Research Imaging Center Marsico Hall (UNC) Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC) Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.