NCT04330664CompletedPhase 1
Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)
A Phase 1/2 Trial of MRTX849 in Combination With TNO155 in Patients With Advanced Solid Tumors With KRAS G12C Mutation KRYSTAL 2
Source: ClinicalTrials.gov · Last updated 4 Apr 2025
Brief summary (registry, in English)
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 in combination with TNO155 in patients with advanced solid tumors that have a KRAS G12C mutation.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 86 (actual)
- First submitted
- 30 Mar 2020
- Start date
- 7 Apr 2020
- Primary completion date
- 29 Jul 2022
- Lead sponsor
- Mirati Therapeutics Inc.
- Diseases
- Lung cancer, Pancreatic cancer, Colorectal cancer
- NCT number
- NCT04330664
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 86
- From 7 Apr 2020 to the primary completion date, 29 Jul 2022
- 17 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions likely to alter absorption of study treatment or result in inability to swallow
- Other active cancer
- Cardiac abnormalities
Who the study is looking for
- Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation (phase 2 must be either Non-Small Cell Lung Cancer or Colorectal Cancer)
- Unresectable or metastatic disease
- No available treatment with curative intent
- Adequate organ function
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (17)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 002-808 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 002-804 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 002-828 Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Local Institution - 002-809 D Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Local Institution - 002-809 B Coordinator of this site? Confirm its status | Creve Coeur | United States | Unknown status |
| Local Institution - 002-805 Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Local Institution - 002-810 Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Local Institution - 002-806 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 002-813 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 002-811 Coordinator of this site? Confirm its status | Novi | United States | Unknown status |
| Local Institution - 002-803 Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| Local Institution - 002-801 Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Local Institution - 002-809 E Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Local Institution - 002-809 A Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Local Institution - 002-809 Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Local Institution - 002-809 C Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Local Institution - 002-942 Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.