NCT04331535Active, not recruiting
The Genomic Medicine at VA Study
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1071 (actual)
- First submitted
- 31 Mar 2020
- Start date
- 17 Jul 2020
- Primary completion date
- 31 Jan 2026
- Lead sponsor
- Boston VA Research Institute, Inc.
- Diseases
- Prostate cancer, Coronary artery disease, Atrial fibrillation, Colorectal cancer, Type 2 diabetes
- NCT number
- NCT04331535
What you commit to
- Study type: Interventional
- Participants enrolled: 1071
- From 17 Jul 2020 to the primary completion date, 31 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Patients will be ineligible if they:
- Have a known diagnosis of at least one of the six diseases of interest
- Are younger than age 50 or older than age 70
- Are pregnant
- Are incarcerated or institutionalized
Who the study is looking for
- Age 50-70 years at enrollment
- No known diagnosis of the following conditions, initially screened by the International Classification of Disease (ICD) codes or other electronic health record (EHR) data using validated methods and then confirmed with potential patient-participants during recruitment: coronary artery disease, atrial fibrillation, type 2 diabetes, colorectal cancer, breast cancer, prostate cancer
Age in the registry: 50 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Boston Healthcare System Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.