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NCT04337255Active, not recruiting

Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients

MIND Diet and Dementia Prevention in Ischemic Stroke Patients

Source: ClinicalTrials.gov · Last updated 2 Oct 2026

Brief summary (registry, in English)

To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular disease in a Phase Ill randomized controlled trial of 250 patients hospitalized for acute ischemic stroke, aged 55 years or older, and without dementia who are discharged home following hospitalization.

Status (registry)
Active, not recruiting
Study type
Interventional
Enrollment
266 (actual)
First submitted
12 Dec 2019
Start date
14 Dec 2021
Primary completion date
31 Jul 2026
Lead sponsor
Rush University Medical Center
NCT number
NCT04337255

What you commit to

  • Study type: Interventional
  • Participants enrolled: 266
  • From 14 Dec 2021 to the primary completion date, 31 Jul 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Criteria the registry did not label

  • Inclusion Criteria
  • Men and women, 55 years of age - inclusive- or older
  • Acute stroke as defined by an acute focal neurological deficit in combination with one of the following: acute ischemic infarct (stroke) as documented by either a DWl positive lesion on MR imaging or a new lesion on a delayed CT scan
  • Written informed consent by patient prior to study participation
  • Willingness to complete all assessments and participate in follow-up
  • Willing to participate and give informed consent
  • Adequate Visual and auditory acuity to undergo neuropsychological testing
  • Exclusion criteria
  • CDR\>=0.5
  • Nuts, berries, olive oil, or fish allergies
  • Use of medications to treat Alzheimer's disease or Parkinson's disease
  • Aphasia
  • Conditions of psychosis or bipolar disorder judged by study investigators to potentially interfere with study compliance over 3 years
  • Report of alcohol or substance abuse within six months, or heavy alcohol consumption (\>2 drinks/d women; \>3 drinks/d men)
  • Unstable or recent onset of cardiovascular disease, such as myocardial infarction within six months or presence of congestive heart failure (Stages II-IV)
  • Cancer treatment \<= 5 years except non-melanoma skin cancer , basal cell skin cancer (this criterion may be waived at the site PI's discretion)
  • Illness that might be associated with weight change, such as a history of stomach or gastrointestinal conditions (Inflammatory Bowel Disease, Crohn's Disease, malabsorption, colostomy, bowel resection, gastric bypass surgery, etc.)
  • History of liver disease, HIV or Hepatitis C
  • An intracerebral hemorrhage as documented on CT or MRI
  • Pre- hospitalization diagnosis of dementia or mild cognitive impairment
  • Patients presenting one of the following diseases: cerebral venous thrombosis, traumatic cerebral hemorrhage, intracerebral hemorrhage because of a known or image-guided assumed vascular malformation, pure meningeal or intraventricular hemorrhage
  • Patients presenting a malignant disease with life expectancy \< 3 years
  • Residence in a nursing home and thus going back to nursing home upon discharge
  • Participation in an ongoing investigational drug study
  • Exception to these guidelines will be rare but may be considered on a case by case basis at the discretion of the PI's

Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Rush University Medical Center
Coordinator of this site? Confirm its status
ChicagoUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.