NCT04341779Active, not recruiting
Simplifying Treatment and Monitoring for HIV (STREAM HIV)
Simplifying Treatment and Monitoring for HIV (STREAM HIV): Point-of-Care Urine Tenofovir Adherence and Viral Load Testing to Improve HIV Outcomes in South Africa
Source: ClinicalTrials.gov · Last updated 19 Feb 2026
Brief summary (registry, in English)
This study seeks to determine the clinical efficacy and cost effectiveness of implementing an integrated model for HIV monitoring using point of care (POC) tenofovir (TFV) adherence testing and POC viral load (VL) monitoring in improving ART adherence, maintaining durable VL suppression, and improving retention in care among HIV-positive individuals initiating first-line tenofovir disoproxil fumarate (TDF)-based ART in South Africa.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 539 (actual)
- First submitted
- 7 Apr 2020
- Start date
- 4 Feb 2021
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- University of Washington
- Diseases
- HIV
- NCT number
- NCT04341779
What you commit to
- Study type: Interventional
- Participants enrolled: 539
- From 4 Feb 2021 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Does not plan to continue receiving HIV care at the CDC Clinic
Other illness
- Per the decision or opinion of the PI (for example, a clinically significant acute or chronic medical condition or circumstances that would make the patient unsuitable for participation or jeopardize the safety or rights of the participant
Who the study is looking for
- HIV-positive
- ≥16 years old
- Initiating a TDF-based, first-line ART regimen
- Do not self-report being on an ART regimen in the prior month
- Willing/able to provide written informed consent
Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal Coordinator of this site? Confirm its status | Durban | South Africa | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.