NCT04360200Recruiting
Cognitive Impairment in Ageing People
Cognitive Impairment in Ageing People: A Longitudinal Observational Prospective Study
Source: ClinicalTrials.gov · Last updated 14 Sept 2020 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Mild cognitive impairment (MCI) and neurocognitive disorder such as Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. At present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. The study will construct a prospective cohort to establish database that provide not only comprehensive epidemiological data on the MCI and neurocognitive disorder in ageing people, but also complete the construction of biological samples bank and clinical diagnosis and treatment information database. Using the database, the study will identify the conversion rates from MCI to dementia and risk factors for the progression from MCI to dementia or AD. The study will also apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. The study have goals to identify and validate imaging and blood/CSF biomarkers for the early detection and tracking of cognitive disorders.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 5000 (estimated)
- First submitted
- 12 Apr 2020
- Start date
- 1 Apr 2020
- Primary completion date
- 31 Dec 2040
- Lead sponsor
- Yamei Tang
- Diseases
- Alzheimer disease
- NCT number
- NCT04360200
What you commit to
- Study type: Observational
- Planned participants: 5000
- From 1 Apr 2020 to the primary completion date, 31 Dec 2040
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncooperative subjects that have serious organic diseases, or have a history of mental illness, or have physical disability (including severe aphasia).
- Suffering from serious physical or mental illness.
Other
- Subjects with mental retardation.
- Refuse to have blood sampling, imaging and other examinations.
- Contraindications of MR scanning.
Who the study is looking for
- Patients over 50 years old.
- Sign informed consent.
- According to DSM-IV, the diagnostic standard of dementia was not met.
- The clinical dementia rating (CDR) was 0.5.
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sun Yat-sen Memorial Hospital, Sun Yat-sen University Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.