NCT04364256Completed
Muscle Stimulation for Physical Function During Stem Cell Transplant
Neuromuscular Electrical Stimulation for Physical Function Maintenance During Hematopoietic Stem Cell Transplantation
Source: ClinicalTrials.gov · Last updated 2 Jan 2026
Brief summary (registry, in English)
Some blood, bone marrow, and lymphatic (hematologic) cancers such as Hodgkin/Non-Hodgkin lymphomas, chronic lymphocytic leukemia, and multiple myeloma, are over-represented in Veterans due to exposures including Agent Orange and an increased percentage of patients of African American ethnicity. Hematologic transplantation (HCT) is a common treatment for these cancers, but often leads to deconditioning, fatigue, muscle atrophy, and poor quality of life, which are associated with complications such as hospitalization and infection. Despite the significance of these symptoms, there are no approved treatments to prevent/reverse these long-term effects. The cancer itself, side effects of chemotherapy, and sedentary behavior, contribute to these effects. Although exercise before and after HCT has helped reduce these effects, it is inconsistently recommended to patients and most remain sedentary through and after treatment. The investigators are testing an alternative exercise strategy, neuromuscular electrical stimulation, to maintain physical function quality of life after HCT.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 46 (actual)
- First submitted
- 20 Apr 2020
- Start date
- 14 May 2021
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Multiple myeloma
- NCT number
- NCT04364256
What you commit to
- Study type: Interventional
- Participants enrolled: 46
- From 14 May 2021 to the primary completion date, 30 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- concomitant study inclusion in other nutritional or physical exercise interventional trials
- concomitant use of anabolic agents
- history of prior hematologic stem cell transplant
Other illness
- active deep vein thrombosis or thrombophlebitis
- untreated hemorrhagic disorders
- rhabdomyolysis or other muscle conditions where NMES is contraindicated
- implanted cardiac device
Lab values
- reduced renal clearance defined as Stage 4 chronic kidney disease (glomerular filtration rate \<45 ml/min/1.73 m2)
Other
- baseline patient-reported muscle soreness of 5-6 on the soreness likert scale that is unrelated to recent physical exertion
- probable or definitive liver cirrhosis
Who the study is looking for
- adequate cognitive and language ability to provide consent
- Veteran enrolled in MTU at VAPSHCS for planned standard of care autologous HCT
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Puget Sound Health Care System Seattle Division, Seattle, WA Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.