NCT04366518RecruitingEarly phase 1
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Source: ClinicalTrials.gov · Last updated 5 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Auditory hallucinations are among the most distressing aspects of psychotic illness, and between 10 and 30% of people with hallucinations do not respond to antipsychotic medications. The authors have used computational modeling of behavior to link brain activity to development of auditory hallucinations in the hope of guiding new treatment development. The proposed studies take the first step toward individualized treatment approaches to hallucinations by attempting causal, pharmacological manipulation of relevant model parameters underlying these phenomena.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 35 (estimated)
- First submitted
- 24 Mar 2020
- Start date
- 15 Jul 2021
- Primary completion date
- Aug 2032
- Lead sponsor
- Yale University
- Diseases
- Schizophrenia
- NCT number
- NCT04366518
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 35
- From 15 Jul 2021 to the primary completion date, Aug 2032
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current substance dependence or active use as determined by drug test.
- Concurrent participation in any other intervention study
- Current use of any cholinergic or anticholinergic medication
Other illness
- Contraindications for MR scanning including metallic implants of any kind, pacemakers and history of accidents with metal, claustrophobia
- History of seizures
- History of violence
- History of suicide
- History of urinary retention
- History of delirium
- History of asthma, diabetes, and cardiovascular disease
- Evidence of cardiovascular disease on EKG
Other
- Any neurological, medical or developmental problem that is known to impair cognition significantly
- Pregnancy (determined by urine pregnancy test)
- Individuals who have been on dopamine-2 antagonists for less than 6 months (to limit risk of EPS)
Who the study is looking for
- Age 18-65
- English speaking
- Right handedness
- Diagnosed with schizophrenia schizoaffective, schizophreniform, schizotypal, or brief psychotic disorder
- History of auditory verbal hallucinations occurring at least weekly
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Connecticut Mental Health Center Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.