NCT04377594Active, not recruiting
Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.
Individually DEsigned Ablation of Low Voltage Areas in Patients With Persistent Atrial Fibrillation, a Randomized Controlled Multicenter Trial
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
Brief summary: The objective of this study is to compare two different ablation strategies in participants with persistent atrial fibrillation and fibrotic areas in the left atrium. The participant will be randomized to pulmonary vein isolation or pulmonary vein isolation plus ablation of fibrotic areas.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 23 Apr 2020
- Start date
- 20 May 2020
- Primary completion date
- 10 Apr 2026
- Lead sponsor
- Karolinska University Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT04377594
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 20 May 2020 to the primary completion date, 10 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- LA dimension \>55 mm as determined by an echocardiography within the previous year
- Prior surgical or percutaneous AF ablation procedure or atrioventricular-nodal ablation
Other illness
- Acute coronary syndrome or coronary artery bypass surgery within 12 weeks
- Severe aortic or mitral valvular heart disease using the ESC guidelines
- Congenital heart disease
- Medical condition likely to limit survival to \< 1 year
- New York Heart Association (NYHA) class IV heart failure symptoms
- Renal failure requiring dialysis
- History of non-compliance to medical therapy
Other
- Contraindication to oral anticoagulation
- AF due to reversible cause
- Pregnant and fertile women without anticonception
- Unable or unwilling to provide informed consent
Who the study is looking for
- ECG-documented persistent or long-standing persistent atrial fibrillation according to European Society of Cardiology (ESC) definition
- Symptoms e. g. palpitations, dyspnea, tiredness that is due to the atrial fibrillation.
- Suitable candidate for catheter ablation.
- Tried one or more antiarrhythmic drugs or unwilling to try antiarrhythmic drugs
- Age ≥18 years.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Karolinska University Hospital Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
Related publications
- Low-Voltage Ablation in Persistent Atrial Fibrillation: The IDEAL-AF Randomized Clinical Trial.JAMA · 2026 · PMID 42669133
This page is information, not medical advice. Discuss any trial with your doctor.