NCT04379999CompletedEarly phase 1
Atorvastatin ± Aspirin in Lynch Syndrome Syndrome
Impact of Atorvastatin ± Aspirin on Colorectal Biomarkers in Patients With Lynch Syndrome: a Pilot Study
Source: ClinicalTrials.gov · Last updated 7 Aug 2025
Brief summary (registry, in English)
The goal of this study is to investigate that a common cholesterol lowering agent (atorvastatin) alone or combining with a nonsteroidal anti-inflammatory drug (aspirin) would reduce the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.
- Status (registry)
- Completed
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 43 (actual)
- First submitted
- 3 Jan 2020
- Start date
- 10 Sept 2018
- Primary completion date
- 4 Aug 2025
- Lead sponsor
- Fox Chase Cancer Center
- NCT number
- NCT04379999
What you commit to
- Study type: Interventional · Early phase 1
- Participants enrolled: 43
- From 10 Sept 2018 to the primary completion date, 4 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have active cancer or are less than 3 years post hormonal maintenance therapy for cancer
Age
- Are \<18 years of age
Other
- Unable to read and sign an informed consent document in English
- Have statin intolerance or contraindication for aspirin or atorvastatin use
- Are pregnant or are actively breast feeding
Who the study is looking for
- Subjects who are 18 years of age or older
- Able to read and sign an informed consent document in English
- Eligible subjects will have molecular evidence of Lynch Syndrome (mutation in MLH1, MSH2, MSH6, EPCAM or PMS2)
- History of colorectal cancer if surgically cured and \> 1 year from completion of adjuvant chemotherapy
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fox Chase Cancer Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.