NCT04389437Recruiting
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases. These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD. No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 450 (estimated)
- First submitted
- 12 May 2020
- Start date
- 26 Jun 2020
- Primary completion date
- Jun 2027
- Lead sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Diseases
- Lewy body dementia, Alzheimer disease
- NCT number
- NCT04389437
What you commit to
- Study type: Interventional
- Planned participants: 450
- From 26 Jun 2020 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis)
- history of retinal pathology
- history of taking ethambutol for more than 2 months
- history of takingsynthetic antimalarial for more than 2 years
Other
- pregnant or lactating women
- ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder.
- Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) \<10 for patients and 26 for accompanying persons
- MRI contraindication (for patients only)
Who the study is looking for
- Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Fondation A. de Rothschild Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.