NCT04395157Completed
Optimizing Cognitive Remediation
Optimizing Cognitive Remediation in VA Mental Health Rehabilitation Settings
Source: ClinicalTrials.gov · Last updated 25 Feb 2026
Brief summary (registry, in English)
Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA Mental Health Residential Rehabilitation Treatment Programs, Psychosocial Rehabilitation and Recovery Centers and other mental health treatment programs are designed to help Veterans overcome these barriers, but cognitive impairment often seen in Veterans with mental illness limits gains from these settings. Cognitive remediation interventions can be helpful, but they are either "one-size fits all," and thus may not be useful for all Veterans with mental illness, or are too narrow in scope, focusing on specific mental illnesses, limiting generalizability. This project will test whether an objective neurophysiological biomarker, mismatch negativity (MMN), can better match the "right" Veteran to the "right" cognitive remediation treatment regardless of their specific mental health diagnosis.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 12 May 2020
- Start date
- 1 Dec 2020
- Primary completion date
- 1 Jan 2025
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Schizophrenia
- NCT number
- NCT04395157
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 1 Dec 2020 to the primary completion date, 1 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- positive urine drug screen conducted as part of the screening process
Other illness
- intellectual disability or a neurocognitive disorder (i.e. dementia)
Other
- active substance use within the last 30 days
- have acute/ongoing thoughts of self-harm or harming others
Who the study is looking for
- Veterans are currently enrolled in or within 6 weeks of discharge from (as relevant): a VA San Diego Healthcare System (VASDHS) psychosocial rehabilitation and recovery center (PRRC), VASDHS mental health residential rehabilitation treatment program (RRTP), VASDHS acute inpatient hospitalization or VASDHS outpatient mental health treatment
- have a DSM-5 mental illness, including:
- schizophrenia
- schizoaffective disorder
- delusional disorder
- major depressive disorder
- bipolar disorder
- generalized anxiety disorder
- PTSD
- fluent and literate in English
- no impairment in hearing or vision
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA San Diego Healthcare System, San Diego, CA Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.