NCT04397159Recruiting
Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease
Objective and Subjective Measures of Fatigability in Veterans With Chronic Kidney Disease Before and After Flywheel Resistance Plus Aerobic Exercise
Source: ClinicalTrials.gov · Last updated 12 Mar 2026
Brief summary (registry, in English)
The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 13 May 2020
- Start date
- 1 Jun 2022
- Primary completion date
- 1 Apr 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Chronic kidney disease
- NCT number
- NCT04397159
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Jun 2022 to the primary completion date, 1 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- adults diagnosed with acute renal failure/injury within the last 12-months
- musculoskeletal disease
- or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
Other
- non-ambulatory individuals
- adults who do not use the DC VAMC as their main site for renal care
- those who have any uncontrolled cardiovascular
- any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
- additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study
Who the study is looking for
- Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2)
- Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months
- All participants must be able to speak and read English, and demonstrate orientation to person, place, and time
Age in the registry: 50 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington DC VA Medical Center, Washington, DC Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.