NCT04406675Completed
Social Cognition in Patients With Amyotrophic Lateral Sclerosis
Source: ClinicalTrials.gov · Last updated 4 Jun 2026
Brief summary (registry, in English)
Amyotrophic Lateral Sclerosis, also known as Charcot disease, is a neurodegenerative disease evidenced by gradual paralysis of the muscles involved in voluntary motor function. The clinical hallmark of Amyotrophic Lateral Sclerosis is the combination of upper and lower motor neuron signs and symptoms. The most recent studies suggest that up to 50% of Amyotrophic Lateral Sclerosis patients demonstrate mild to moderate cognitive disturbance. Impaired social cognition, including a deficit in the recognition of facial emotions and the identification of vocal prosody, is recognized as a part of the cognitive phenotype of Amyotrophic Lateral Sclerosis, with crucial implications for patients' and caregivers' training. However, studies remain scarce and the data acquired must be supported. The evolution of these manifestations during the disease is still poorly understood. In this study the investigators aim to assess the social cognition capacities of patients with Amyotrophic Lateral Sclerosis compared to healthy matched control subjects.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 58 (actual)
- First submitted
- 13 May 2020
- Start date
- 21 Sept 2020
- Primary completion date
- 29 May 2026
- Lead sponsor
- University Hospital, Angers
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT04406675
What you commit to
- Study type: Interventional
- Participants enrolled: 58
- From 21 Sept 2020 to the primary completion date, 29 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Persons under psychiatric care under duress
Other
- Patient Amyotrophic Lateral Sclerosis and control subject :
- Simultaneous participation in another interventional protocol with experimental treatment
- Inability to perform cognitive study tests
- Pregnant, lactating or parturient women
- Persons deprived of their liberty by administrative or judicial decision
- Persons subject to legal protection measures
- Persons out of state to express their consent
- People not affiliated or not beneficiaries of a social security scheme
- History likely to disturb cognition
Who the study is looking for
- Patient Amyotrophic Lateral Sclerosis :
- Education of at least 7 years
- Native language: French
- Patients Amyotrophic Lateral Sclerosis
- Signature of informed consent to participate in the study
- Accompanied patient
- Control subject :
- People without any pathology
- Education of at least 7 years
- Native language: French
- Signature of informed consent to participate in the study
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Angers Coordinator of this site? Confirm its status | Angers | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.