NCT04412863CompletedPhase 2
Study of VIR-2218 With or Without Pegylated Interferon Alpha-2a for Treatment of Chronic Hepatitis B Virus Infection
A Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of VIR-2218 Alone or in Combination With Pegylated Interferon Alpha-2a
Source: ClinicalTrials.gov · Last updated 16 Apr 2026
Brief summary (registry, in English)
This is a phase 2 study in which subjects with chronic hepatitis B virus (HBV) infection will receive VIR-2218 alone or in combination with pegylated interferon alfa-2a and will be assessed for safety, tolerability, pharmacokinetics, and antiviral activity.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 84 (actual)
- First submitted
- 29 May 2020
- Start date
- 3 Jul 2020
- Primary completion date
- 25 Mar 2024
- Lead sponsor
- Vir Biotechnology, Inc.
- Diseases
- Hepatitis B
- NCT number
- NCT04412863
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 84
- From 3 Jul 2020 to the primary completion date, 25 Mar 2024
- 18 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History or evidence of drug or alcohol abuse
- Any prior receipt of an interferon product
Other illness
- Any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation
- History of intolerance to SC injection
- History of chronic liver disease from any cause other than chronic HBV infection
- History of hepatic decompensation
Other
- Significant fibrosis or cirrhosis
Who the study is looking for
- Male or female of ages 18 - 65
- Chronic HBV infection for \>/= 6 months
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Investigative Site Coordinator of this site? Confirm its status | Birtinya | Australia | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Fitzroy | Australia | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Busan | South Korea | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Chuncheon | South Korea | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Daegu | South Korea | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Yangsan | South Korea | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Batu Caves | Malaysia | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Kajang | Malaysia | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Kuala Lumpur | Malaysia | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Kuantan | Malaysia | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Auckland | New Zealand | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Chiang Mai | Thailand | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Hat Yai | Thailand | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Khlong Luang | Thailand | Unknown status |
| Investigative Site Coordinator of this site? Confirm its status | Khon Kaen | Thailand | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.