NCT04415372Enrolling by invitation
Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 28 Apr 2026
Brief summary (registry, in English)
The overall purpose of this research is to determine whether new macromolecular measures optimized for whole brain (gray matter and white matter) magnetic resonance imaging (MRI), predict neuro-cognitive impairment in multiple sclerosis (MS) patients.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 75 (estimated)
- First submitted
- 29 May 2020
- Start date
- 19 Nov 2021
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- University of Wisconsin, Madison
- Diseases
- Multiple sclerosis
- NCT number
- NCT04415372
What you commit to
- Study type: Observational
- Planned participants: 75
- From 19 Nov 2021 to the primary completion date, 30 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Changes in MS therapy in the last 6 months
- Less than 6 weeks after relapse or corticosteroid use
- Currently taking medication that may affect cognition (e.g. donepezil, rivastigmine, adderall)
Other illness
- History of significant alcohol or drug abuse
- Confounding neurological or cognitive disorders or deficits (stroke, Parkinson's disease, Alzheimer's disease, epilepsy)
- History of developmental or learning disability or attention-deficit/hyperactivity disorder.\\
- history of alcohol/drug abuse
- history of migraines
- developmental or learning disability/attention-deficit/hyperactivity disorder
Other
- Contraindication to MRI
- Current or recent significant migraines
- Sensory or physical impairments that might interfere significantly with cognitive testing
- currently pregnant/breastfeeding
Who the study is looking for
- Clinically definite MS
- Adult age 18 to 60
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Wisconsin - Madison Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.