NCT04420650Completed
Improving Insulin Sensitivity by Non-invasive Brain Stimulation
Source: ClinicalTrials.gov · Last updated 14 Nov 2023
Brief summary (registry, in English)
Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease. In recent studies, the hypothalamus was identified as part of a brain network including higher cognitive regions that is particularly vulnerable to insulin resistance. Furthermore, the central insulin response in this network predicted food craving and hunger. In this project, transcranial direct current stimulation (tDCS) is implemented as a tool to stimulate brain networks. The investigators hypothesize that stimulating the hypothalamus-cognitive network will enhance insulin sensitivity and reduce food intake, food craving and hunger. Furthermore, the project will provide the unique opportunity to investigate novel mechanisms of insulin resistance in participants who have been extensively metabolically characterized.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 44 (actual)
- First submitted
- 26 May 2020
- Start date
- 26 May 2020
- Primary completion date
- 31 Oct 2023
- Lead sponsor
- University Hospital Tuebingen
- Diseases
- Obesity
- NCT number
- NCT04420650
What you commit to
- Study type: Interventional
- Participants enrolled: 44
- From 26 May 2020 to the primary completion date, 31 Oct 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking psychotropic drugs
- Previous bariatric surgery
- Contradictions to a MRI measurement (e.g. metal implants)
Other illness
- History of severe mental or somatic disorders including neurological diseases (incl. epileptic seizures)
- Acute infection within the last 4 weeks
Lab values
- Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men
Other
- Insufficient knowledge of the German language
- Persons who cannot legally give consent
- Pregnancy or lactation
- Current participation in a lifestyle intervention study or a pharmaceutical study
Who the study is looking for
- Body mass index (BMI) between 25.5 and 39.5 kg/m2
- Age between 20 to 66 years of age
- Waist circumference ≥ 80 cm for women, ≥ 94 cm for men
Age in the registry: 20 years to 66 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Clinic Tübingen Coordinator of this site? Confirm its status | Tübingen | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.