NCT04428788CompletedPhase 1
Study to Evaluate the Safety and Tolerability of CC-94676 in Participants With Metastatic Castration-Resistant Prostate Cancer
A Phase 1, Multi-center, Open-label, Dose Finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Cc-94676 in Subjects With Metastatic Castration-resistant Prostate Cancer
Source: ClinicalTrials.gov · Last updated 22 Dec 2025
Brief summary (registry, in English)
The purpose of this study is to assess the safety, tolerability and preliminary efficacy of CC-94676 in men with progressive metastatic castration resistant prostate cancer.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 131 (actual)
- First submitted
- 29 May 2020
- Start date
- 22 Jun 2020
- Primary completion date
- 28 Oct 2025
- Lead sponsor
- Celgene
- Diseases
- Prostate cancer
- NCT number
- NCT04428788
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 131
- From 22 Jun 2020 to the primary completion date, 28 Oct 2025
- 19 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment with an androgen receptor (AR) degrader
- Clinically significant venous thromboembolism within 3 months prior to the first dose of IP
Other illness
- Concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 1 year prior to the first dose of IP
Lab values
- Any significant medical condition, such as uncontrolled infection, laboratory abnormality, or psychiatric illness
- Other protocol-defined inclusion/exclusion criteria apply
Who the study is looking for
- Must have histologically or cytologically confirmed adenocarcinoma of the prostate
- Progressed on androgen deprivation therapy (ADT) and at least one prior secondary hormonal therapy approved for castration-resistant prostate cancer (CRPC)
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (19)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 120 Coordinator of this site? Confirm its status | Allentown | United States | Unknown status |
| Local Institution - 117 Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Local Institution - 108 Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Local Institution - 104 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 107 Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Local Institution - 106 Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Local Institution - 102 Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Local Institution - 119 Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Local Institution - 111 Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| Local Institution - 112 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 105 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 109 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 113 Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Local Institution - 101 Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Local Institution - 103 Coordinator of this site? Confirm its status | Sarasota | United States | Unknown status |
| Local Institution - 115 Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Local Institution - 116 Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
| Local Institution - 121 Coordinator of this site? Confirm its status | Thomasville | United States | Unknown status |
| Local Institution - 122 Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.