NCT04431479Active, not recruiting
Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
Predicting the Quality of Response to Specific Treatments (PQRST)
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
This trial collects clinical data and blood samples to predict the quality of response to specific treatments in patients with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Collecting and analyzing clinical data and blood samples from patients with cGVHD before and after treatment initiation may help doctors identify changes that may predict treatment response.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 211 (actual)
- First submitted
- 11 Jun 2020
- Start date
- 29 Jun 2020
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- Fred Hutchinson Cancer Center
- NCT number
- NCT04431479
What you commit to
- Study type: Observational
- Participants enrolled: 211
- From 29 Jun 2020 to the primary completion date, 1 Jul 2027
- 10 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled psychiatric disorder
Other
- Inability to comply with study procedures
- Anticipated survival \< 6 months
Who the study is looking for
- Adults age 18 or older
- Prior allogeneic stem cell transplant, with any graft source, donor type, and GVHD prophylaxis
- No evidence of persistent or progressive malignancy at the time of enrollment
- Agrees to be evaluated at the transplant center before a new line of treatment is started (may be concurrent with the enrollment visit), and later between 2-6 weeks, 3 months and 6 months after index treatment is started or if an additional new therapy is started before 6 months
- Signed, informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vancouver General Hospital/BC Cancer Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
| Dana-Farber Harvard Cancer Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Cleveland Clinic Foundation Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| University of Florida Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| University of Minnesota/Masonic Cancer Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Vanderbilt University/Ingram Cancer Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Fred Hutch/University of Washington Cancer Consortium Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Moffitt Cancer Center Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.