NCT04436731CompletedEarly phase 1
Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Brief summary (registry, in English)
Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. This project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics.
- Status (registry)
- Completed
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 73 (actual)
- First submitted
- 8 Jun 2020
- Start date
- 9 Dec 2020
- Primary completion date
- 2 Jul 2026
- Lead sponsor
- University of Missouri-Columbia
- Diseases
- Obesity
- NCT number
- NCT04436731
What you commit to
- Study type: Interventional · Early phase 1
- Participants enrolled: 73
- From 9 Dec 2020 to the primary completion date, 2 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prescription medications, Sensitivity to lidocaine
Other illness
- Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- Nerve/neurologic disease
- Cardiovascular, hepatic, renal, respiratory disease
- Diabetes, Polycystic ovarian syndrome
Other
- Pregnancy, breastfeeding, oral hormonal contraceptive use
- Diagnosed sleep apnea or Oxygen desaturation index \>10 events/hr
- Current smoking/Nicotine use
- Blood pressure ≥140/90 mmHg
- Communication barriers
Who the study is looking for
- 18-45 years of age (premenopausal)
- Healthy weight (BMI ≥18 and ≤25 kg/m2)
- Obese (BMI ≥30 kg/m2)
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Missouri - Columbia Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.