NCT04447703Completed
Technology-Enhanced Acceleration of Germline Evaluation for Therapy, TARGET Study
Technology-Enhanced Acceleration of Germline Evaluation for Therapy - The TARGET Study
Source: ClinicalTrials.gov · Last updated 2 Dec 2025
Brief summary (registry, in English)
This trial performs user testing of a mobile-friendly patient history collection and genetic education tool to improve healthcare providers' understanding of prostate cancer genetic testing. This trial also compares traditional genetic counseling versus a web-based genetic education (WBGE) tool to provide information about genetic testing to men with prostate cancer. The WBGE tool has educational modules on genetic counseling and testing, as well as a patient history collection tool to help providers learn which patients may carry genetic mutations and may be considered for genetic counseling and genetic testing. The purpose of this research is to use technology to deliver information on genetic testing for prostate cancer to patients to help them decide whether or not to receive genetic testing.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 346 (actual)
- First submitted
- 23 Apr 2020
- Start date
- 27 Aug 2020
- Primary completion date
- 9 Aug 2022
- Lead sponsor
- Thomas Jefferson University
- Diseases
- Prostate cancer
- NCT number
- NCT04447703
What you commit to
- Study type: Interventional
- Participants enrolled: 346
- From 27 Aug 2020 to the primary completion date, 9 Aug 2022
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having had prior germline genetic testing for inherited cancer risk (pertains to aim 2)
Other illness
- Mental or cognitive impairment that interferes with ability to provide informed consent
Age
- Age \< 18 years
Other
- Non-English speaking
Who the study is looking for
- AIM 1: Medical oncologists, radiation oncologists and urologists spanning Veterans Affairs (VA), academic, and community settings
- AIM 2: Any English speaking man \>= 18 with PCA who has computer and web-access and meets any one of the following:
- Metastatic disease
- T3a or higher
- Prostate specific antigen (PSA) \> 20
- Grade group 4 or higher
- Intraductal or cribriform histology
- Biochemical recurrence
- Ashkenazi Jewish ancestry
- Family history criteria (see below) \*\* Family history: If any one of the following levels are met, the person is eligible:
- Level 1: \>= 1 close blood relative (first degree relative \[FDR\], second degree relative \[SDR\], third degree relative \[TDR\]) diagnosed with breast cancer =\< age 50 or the following cancers at any age: pancreatic, ovarian, or metastatic or intraductal/cribriform prostate cancer
- Level 2: \>= 2 close blood relatives (FDR, SDR, TDR) on same side of the family with breast or prostate cancer at any age
- Level 3: one brother, father, or \>= 2 family members (close blood relatives - FDR, SDR, TDR) on the same side of the family diagnosed with prostate cancer at \< 60
- Level 4: \>= 3 cancers on the same side of the family (especially if diagnosed =\< 50): bile duct, breast, colorectal, endometrial, gastric, kidney, melanoma, ovarian, pancreatic, prostate (grade groups 2-5 if known), small bowel, or urothelial
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| New York University Langone Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| VA New York Harbor Health System- Manhattan Campus Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Sidney Kimmel Cancer Center at Thomas Jefferson University Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| University of Washington/ SCCA Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Associated Medical Professions of New York Coordinator of this site? Confirm its status | Syracuse | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.