NCT04452305Recruiting
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Source: ClinicalTrials.gov · Last updated 22 Apr 2026
Brief summary (registry, in English)
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 18 Jun 2020
- Start date
- 10 Nov 2023
- Primary completion date
- 28 Dec 2029
- Lead sponsor
- University of Pittsburgh
- Diseases
- Childhood cancers
- NCT number
- NCT04452305
What you commit to
- Study type: Interventional
- Planned participants: 10
- From 10 Nov 2023 to the primary completion date, 28 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants considered to be high risk for surgical complications
Other illness
- Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
- Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
Who the study is looking for
- Male participant at least in Tanner stage 3
- Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
- Healthy enough to undergo anesthesia
- Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant
Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Magee-Womens Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.