Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents

Other illness

• Physical or intellectual impairment precluding protocol adherence.
  • Additional exclusion criteria for respiratory disease population:
• Known malignancy, active smoker (passive smoke exposure is not an exclusion criterium), known inflammatory diseases (e.g. autoimmune disease) that require medical and/or pharmacological treatment and is associated with an inflammatory response, relevant congenital defects
  • Additional exclusion criteria for neurological disease population:
• Known malignancy, active smoker (passive smoke exposure is not an exclusion criterium), known inflammatory diseases (e.g. autoimmune disease) that require medical and/or pharmacological treatment and is associated with an inflammatory response, relevant congenital defects.
  • Additional exclusion criteria for T1D population:
• Known malignancy, active smoker (passive smoke exposure is not an exclusion criterium), relevant congenital defects.

• Age 0 ≤ 22 years at study entry and signed informed consent
  • Additional inclusion criteria for respiratory disease population:
• Acute disease: - Acute signs for a respiratory disease, indicated by e.g. increased work of breathing (e.g. dyspnea, increased respiratory rate), cough or wheezing.
• Chronic disease: - Suspected or confirmed chronic airway disease (e.g. asthma).
  • Additional inclusion criteria for neurological disease population:
• Acute disease: - Acute presentation or report within 24 hours of any signs of neurological deficit (motor function, sensoneural, or verbal).
• Chronic disease: - Confirmed chronic neurologic disease (e.g. childhood epilepsy).
  • Additional inclusion criteria for T1D disease population:
• Acute disease: - Hyperglycemia and/or pH (venous) \<7.3, bicarbonate \>10 mmol/L, increased levels of acetone in blood or urine in the context of newly diagnosed or known T1D.
• Chronic disease: - Confirmed diagnosis of T1D