NCT04464746Completed
Therapeutic Adherence in Uncontrolled Arterial Hypertension
Therapeutic Adherence in Uncontrolled Arterial Hypertension: Selective Detection by Urine Antihypertensive Drugs or Metabolits Analysis and Effectiveness of a Program to Improve Compliance
Source: ClinicalTrials.gov · Last updated 5 Jun 2025
Brief summary (registry, in English)
In hypertension, highly prevalent, up to 10-15% of hypertensive patients have uncontrolled blood pressure despite being treated with ≥3 drugs, which is known as resistant hypertension. Resistant arterial hypertension, together with difficult-to-control hypertension, has a worse cardiovascular prognosis than controlled hypertension. In addition, data on therapeutic adherence in arterial hypertension show that 1 in 2 hypertensive patients do not fully or partially comply with the indicated therapeutic prescription. The determination of antihypertensive drugs or their metabolites in urine seems to be a good indicator of therapeutic adherence. On the other hand, the implementation of a specific program to improve knowledge of the disease and its risks and promote therapeutic adherence could improve the control of hypertension and reduce the associated morbidity and mortality.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 47 (actual)
- First submitted
- 4 Mar 2020
- Start date
- 1 Jul 2018
- Primary completion date
- 20 Dec 2023
- Lead sponsor
- Parc de Salut Mar
- Diseases
- High blood pressure
- NCT number
- NCT04464746
What you commit to
- Study type: Interventional
- Participants enrolled: 47
- From 1 Jul 2018 to the primary completion date, 20 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients receiving treatment with Barnidipino / Felodipine / Lercanidipine / Manidipine / Nifedipine / Verapamil / Eplerenone
Other illness
- secondary arterial hypertension
- Recent history of major vascular episode
Other
- pregnant women
- Impossibility to perform a 24-hour blood pressure monitoring, or poor quality results.
Who the study is looking for
- patients aged ≥18 years
- diagnosis of resistant hypertension with treatment superior to 3 drugs at maximum dose, one of them being a diuretic
- uncontrolled hypertension treated with 2 drugs at the maximum effective doses tolerated
- the prescribed treatment must be stable for the last 2 months
- given informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.