NCT04471779Completed
Information About Alzheimer's Disease for Latinos in New York City
The IDEAL Study: Information About Alzheimer's Disease for Latinos in New York City
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
This study will assess the psychosocial and behavioral impacts of receiving Alzheimer's disease genetic risk assessment incorporating APOE genotypes among Latinos in northern Manhattan. The investigators will conduct a longitudinal, community-based study with a mixed methods design. Participants will be randomized to learn about their lifetime risk of late-onset Alzheimer's disease (AD) based either on (a) Latino ethnicity and family history alone (genotype nondisclosure group), or (b) the same factors plus APOE genotype (genotype disclosure group). Responses will be evaluated at 6 weeks, 9 months, and 15 months after risk assessment. In the quantitative component of the study, the investigators will assess psychosocial outcomes, memory test performance, and health-related behaviors. In the qualitative component of the study, the investigators will investigate the lived experience of receiving personal AD risk information, using a stress and coping theoretical framework.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 374 (actual)
- First submitted
- 9 Jul 2020
- Start date
- 13 Aug 2021
- Primary completion date
- 3 Oct 2025
- Lead sponsor
- Columbia University
- Diseases
- Alzheimer disease
- NCT number
- NCT04471779
What you commit to
- Study type: Interventional
- Participants enrolled: 374
- From 13 Aug 2021 to the primary completion date, 3 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- previously tested for APOE
Other illness
- has Alzheimer's disease
- has a family history consistent with autosomal dominant, early onset Alzheimer's disease
Age
- not in applicable age range
Other
- does not self-identify as Latino
- does not reside in target neighborhoods
- has a positive screen for suicidality in Baseline Survey (any response other than "not at all" to PHQ-9 item, "thoughts that you would be better off dead or of hurting yourself in some way")
Who the study is looking for
- self-identified as Latino or Hispanic
- age 40-64 years
- current residence in target neighborhoods: Washington Heights, Inwood, Hamilton Heights, Central Harlem, East Harlem, Morningside Heights, Manhattanville, or Striver's Row, New York
Age in the registry: 40 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Columbia University Irving Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
Related publications
- Psychological impacts of APOE genotype disclosure among Latinos in New York City: a randomized controlled trial.Alzheimers Dement · 2026 · PMID 42712082
This page is information, not medical advice. Discuss any trial with your doctor.