NCT04471961Completed
Analyse of Tumour and Constitutional DNA for the Study of the Determinism in Child Neoplasia
Source: ClinicalTrials.gov · Last updated 22 Jun 2026
Brief summary (registry, in English)
Background. Cancer is the leading cause of death by disease in children. Most pediatric tumors differ from adult tumors in terms of biological and clinical characteristics. In children, the part of genetic determinism could be higher since the role of environmental factors may be less pronounced than in adults and that a young age at onset is a main feature of genetic cancer predisposition. Recent studies suggested that a number of genetic predisposition remains to be characterized. Methods. Trio-Based whole exome sequencing of germline DNA from patients (children and adults diagnosed with cancers between 0 and 17 years) and parents will be performed prospectively in a multicentric study including 40 unselected cases of malignant tumor. Participating hospitals will include the CHU of Montpellier, the CHU de Nice and the AP-HP. Tumor analysis will include whole exome analysis and transcriptome for the identification of therapeutic target and contribute to confirm potential link between constitutive mutations and tumor phenotype (such as loss of expression, loss of heterozygosity). Perspectives. This pediatric oncology study proposing a global approach integrating trio-based whole exome sequencing, somatic DNA and RNA analysis will improve the recognition of genetic predisposition and the characterization of target therapies in children with cancer.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 100 (actual)
- First submitted
- 10 Jul 2020
- Start date
- 9 Jul 2020
- Primary completion date
- 12 Jun 2025
- Lead sponsor
- University Hospital, Montpellier
- Diseases
- Childhood cancers
- NCT number
- NCT04471961
What you commit to
- Study type: Interventional
- Participants enrolled: 100
- From 9 Jul 2020 to the primary completion date, 12 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Failure to obtain written informed consent from parents (for themselves and their minor child) after a period of reflection Yes No
Other
- The patient's parents are under guardianship or trusteeship or under legal protection Yes No
- No affiliation to or beneficiary of a French social security scheme (for biological parents and the patient)
Who the study is looking for
- The patient has a solid or haematological malignancy, either familial forms or isolated cases diagnosed between the ages of 0 and 17 years.
- The minor patient and both biological parents are available to participate in the study OR
- The adult patient and one or both parents are available to participate in the study.
- The patient's parents must have given their free and informed consent and signed the consent for the minor's participation in the study.
- The patient's parent(s) must have given free and informed consent and the patient of legal age must have signed the consent for participation in the study.
- The patient must be affiliated or beneficiary of a Frrench social security scheme.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.