NCT04477330Recruiting
Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal
Cortical Priming to Optimize Gait Rehabilitation: Renewal
Source: ClinicalTrials.gov · Last updated 11 May 2026
Brief summary (registry, in English)
Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mechanisms that are associated with response to the intervention.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 9 Jul 2020
- Start date
- 1 Sept 2020
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Stroke
- NCT number
- NCT04477330
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Sept 2020 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Metal implants in the head or face
Other illness
- General exclusion criteria
- Severe osteoporosis
- Contracture-limiting range of motion of lower limb
- Score of more than 2 on the Modified Ashworth Scale (indicating increased muscle tone through ankle range of motion)
- Uncontrolled anti-spasticity medications during the study period
- Score less than 6 on the Fugl-Meyer Sensory Assessment Scale for the Lower Limb
- Cardiorespiratory or metabolic diseases (e.g. cardiac arrhythmia, uncontrolled hypertension or diabetes, chronic emphysema)
- Unhealed decubiti, persistent infection
- Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)\<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task.
- Lesions involving the brainstem and cerebellum
- Failure to pass the graded exercise stress test
- TMS exclusion criteria
- Implanted cardiac pacemaker
- History of seizures or epilepsy
- Currently under medication that could increase motor excitability and lower seizure threshold
- Skin hypersensitivity
- History of contact dermatitits
- History of allodynia and/or hyperalgesia
- Any other skin or scalp condition that could be aggravated by tDCS
Other
- Unexplained, recurring headaches
- Skull abnormalities or fractures
- Concussion within the last 6 months
- Currently pregnant
- tDCS exclusion criteria
Who the study is looking for
- Age greater than 18 years
- First ever monohemispheric stroke \> 3 months since onset
- Residual hemiparetic gait deficits (e.g. abnormal gait pattern)
- Able to walk for 5 minutes at self-paced speed. Handheld assistive device is acceptable.
- Walking speed lesser than 1.2 m/s
- Lower limb Fugl-Meyer Motor score between 15-30
- At least 5 deg of ankle dorsiflexion necessary to perform the ankle-tracking task
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Physical Therapy Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.