NCT04479072RecruitingPhase 4
Aspirin and Preeclampsia
Aspirin to Prevent Cardiac Dysfunction in Preeclampsia
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 13 Jul 2020
- Start date
- 15 Feb 2021
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- University of Chicago
- Diseases
- High blood pressure
- NCT number
- NCT04479072
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 180
- From 15 Feb 2021 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Co-enrolled in other trials that might affect the patients taking the study medication, as determined by the PI.
- Clear indication for aspirin therapy or contraindication to aspirin therapy
- Currently or planning on taking any nonsteroidal anti-inflammatory drugs while they are participating in this study.
Other illness
- Patients with preexisting cardiomyopathy, chronic hypertension, ischemic or valvular heart disease, pulmonary disease, diabetes mellitus, chronic kidney disease, multiple gestation
- Aspirin allergy
- Clinically significant conditions that might limit adherence to trial regimen (e.g., peptic ulcer disease, history of gastrointestinal bleeds, bleeding disorders)
Other
- We will exclude patients in labor
- Plan to deliver outside of the participating site
- Those who cannot provide consent
Who the study is looking for
- Pregnant Adults between 18 and 45 years of age
- Diagnosed with preeclampsia
- Presenting for delivery with a singleton gestation.
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Chicago Hospital Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.