NCT04482179CompletedPhase 1
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease
A Phase II, Randomized, Blinded Study of Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for the Treatment of Chronic Aphasia - Alzheimer Disease Sub-study
Source: ClinicalTrials.gov · Last updated 15 Sept 2025
Brief summary (registry, in English)
Impaired verbal communication is a cardinal symptom of Alzheimer Disease (AD) and the source of enormous distress and disability. Effective therapies for this deficit are lacking. In light of the emerging literature demonstrating that Transcranial Magnetic Stimulation (TMS) improves general cognition in subjects with Alzheimer Disease (AD), the investigators propose to study the effectiveness of TMS as a therapy for impaired verbal communication. The hypothesis to be tested is that TMS combined with Constraint Induced Language Therapy (CILT) improves verbal communication more than sham TMS and CILT. A second aim is to use state-of-the-art neuroimaging to understand the mechanisms underlying any beneficial effect of the treatment.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 23 (actual)
- First submitted
- 17 Jul 2020
- Start date
- 19 Feb 2020
- Primary completion date
- 31 Aug 2024
- Lead sponsor
- University of Pennsylvania
- Diseases
- Alzheimer disease
- NCT number
- NCT04482179
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 23
- From 19 Feb 2020 to the primary completion date, 31 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any contraindications to TMS, including uncontrolled seizures, previous brain surgery, and history of tinnitus
Other illness
- History of stroke
- History of seizure
- History of any other significant neurologic disease (e.g., ALS)
- Any significant medical disorder that, in the view of the investigators, could threaten the subject's ability to complete the study (e.g., cancer, significant cardiac disease)
Other
- Significant depression as defined by the Geriatric Depression Scale.
Who the study is looking for
- A diagnosis of mild-moderate AD as defined by the National Institute of Aging - Alzheimer's Disease and Related Disorders Association criteria
- Mild-moderate cognitive impairment, indicated by Mini-Mental Status Exam (MMSE) scores between 23 and 15 inclusive
- Must be right handed as defined by the Edinburgh Handedness Inventory
- Must be a native English speaker
- Must be able to understand the nature of the study, and give informed consent
Age in the registry: 60 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.