NCT04488250Active, not recruiting
Robot-Assisted Rehabilitation After HIV-Associated Stroke: Botswana
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
Today, nearly 37 million people are living with HIV (PLHIV) worldwide and 30 to 40% of them will have neurologic complications leading to disability. Our long-term working hypothesis is that an effective solution for increasing rehabilitation access in Botswana and improving functional outcomes of PLHIV having experienced a stroke with or without HIV uses an affordable robot and mobile health technologies to create a cost-effective intervention strategy. For this project, we test the feasibility of affordable robot therapy.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 30 Apr 2019
- Start date
- 1 Oct 2020
- Primary completion date
- 30 Jul 2026
- Lead sponsor
- University of Pennsylvania
- NCT number
- NCT04488250
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Oct 2020 to the primary completion date, 30 Jul 2026
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- have a history of prior brain injury including lesions to the cerebella or brain stem;
- It is up to the physician to decide if a subject should be excluded due to severe drug and/or alcohol abuse or taking of medication that would impair cognitive ability.
Other illness
- have a history of psychiatric disorder or cardiac problems;
Other
- unable to give consent;
- severely depressed (Becks Depression Inventory-Fast Screener);
- experiencing excessive pain (Visual Analog Scale (VAS) score greater than 4);
- have severe spasticity ( than 3) in muscle tone in elbow/shoulder/wrist hip/knee/ankle using the Ashworth Scale;
- have total paralysis or muscular contractures of upper or lower extremity;
- have open lesions on the upper or lower limbs;
Who the study is looking for
- diagnosis of Stroke (at least 3 months post incident) with or without HIV, age over 18;
- medically stable (Able to tolerate therapy and given the determination as able to go through protocol by physician);
- have neurological function between 5 and 24 as defined by the NIH Stroke Scale (NIHSS);
- have no less than moderate cognitive function as defined by the International HIV-Dementia Scale
- Able to give consent.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Botswana Coordinator of this site? Confirm its status | Gaborone | Botswana | Unknown status |
| Penn Medicine Rittenhouse Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.