NCT04490057CompletedPhase 4
A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV
Source: ClinicalTrials.gov · Last updated 5 Jan 2026
Brief summary (registry, in English)
Many people living with HIV (PLWH) smoke. Smoking in these individuals is often undertreated. This study plans to assess the ability of various clinical pathways involving tobacco treatment medications and contingency management (paying smokers for not smoking) to improve smoking cessation in a group of PLWH.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 323 (actual)
- First submitted
- 22 Jul 2020
- Start date
- 27 Jul 2020
- Primary completion date
- 24 Oct 2024
- Lead sponsor
- Yale University
- Diseases
- HIV
- NCT number
- NCT04490057
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 323
- From 27 Jul 2020 to the primary completion date, 24 Oct 2024
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently using NRT, VAR, or bupropion (defined as use in the prior 7 days);
Other illness
- Life-threatening or unstable medical, surgical, or psychiatric condition;
Other
- Using only non-cigarette nicotine products (i.e., e-cigs, Juul, etc.);
- Self-report or urine testing confirming pregnancy, nursing, or trying to conceive;
- Inability to provide at least one collateral contact (family member or friend);
- Living out of state;
- Unable to read or understand English (except at Mount Sinai site).
Who the study is looking for
- HIV positive;
- \>= 18 years old
- Receiving HIV care at Yale-New Haven Hospital, Bridgeport Hospital, Mount Sinai Hospital, or SUNY Downstate STAR clinic;
- Have smoked \>= 100 cigarettes in lifetime;
- Currently smokes some days or every day;
- Smokes, on average, \>= 5 cigarettes per day;
- Able to provide written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bridgeport Hospital Infectious Disease Clinic Coordinator of this site? Confirm its status | Bridgeport | United States | Unknown status |
| SUNY Downstate STAR Clinic Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| Yale University School Of Medicine Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Icahn School of Medicine at Mount Sinai Coordinator of this site? Confirm its status | New York | United States | Unknown status |
Related publications
- Clinical Pharmacists, Medications, and Contingency Management for Targeting Smoking in HIV Clinics: A Randomized Clinical Trial.JAMA Netw Open · 2026 · PMID 41758512
This page is information, not medical advice. Discuss any trial with your doctor.