NCT04503122Completed
Baroreflex Sensitivity in Patients Undergoing Ablation of Atrial Fibrillation
Baroreflex Sensitivity in Patients Undergoing Atrial Fibrillation Ablation: Association With Arrhythmia Recurrences
Source: ClinicalTrials.gov · Last updated 24 Dec 2025
Brief summary (registry, in English)
Atrial fibrillation is the most common arrhythmia. The posterior surface of the left atrium is covered by an extensive network belonging to the autonomic nervous system that can be damaged during the ablation. The involvement of the autonomous nervous system in the genesis and maintenance of atrial fibrillation remains poorly understood. Baroreflex sensitivity is a non-invasive method assessing autonomous nervous system activity. The rate of atrial fibrillation recurrence after ablation is currently high and a better understanding of the mechanisms associated with recurrence is essential to improve selection of the patients who will benefit the most from this procedure. The aim of this study is to evaluate the association between the baroreflex sensitivity and atrial fibrillation recurrences and to analyze the prognostic contribution of the baroreflex measurement compared to other published criteria.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 116 (actual)
- First submitted
- 3 Aug 2020
- Start date
- Jun 2021
- Primary completion date
- Nov 2025
- Lead sponsor
- Poitiers University Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT04503122
What you commit to
- Study type: Observational
- Participants enrolled: 116
- From Jun 2021 to the primary completion date, Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of atrial fibrillation ablation,
Lab values
- Contraindication to the performance of a cardiac CT scan (allergy to iodine, severe renal insufficiency with clearance \<30 ml/mn/m2),
Age
- Age \< 18,
Other
- Inability to calculate the baroreflex sensitivity
- Inability to have continuous ECG recording by subcutaneous Holter,
Who the study is looking for
- Age ≥ 18 years old,
- Patients with paroxysmal atrial fibrillation, hospitalized for atrial fibrillation ablation,
- Assessable baroreflex sensitivity before ablation,
- Free subject, without guardianship or curatorship or subordination,
- Patients benefiting from a Social Security assurance,
- Informed consent signed by the patient after clear and fair information about the study.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.