NCT04504136Completed
Regulation of Mucosal Healing in Inflammatory Bowel Disease
Source: ClinicalTrials.gov · Last updated 30 Sept 2026
Brief summary (registry, in English)
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid or psoriatic arthritis. Patients will be biopsied at baseline and again at a follow-up visit in a "biopsy of the biopsy" approach. These biopsies will be used to reveal patterns about gene expression and mitochondrial function during ulcer healing.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 4 Aug 2020
- Start date
- 30 Apr 2021
- Primary completion date
- 15 Aug 2024
- Lead sponsor
- Terrence A Barrett
- NCT number
- NCT04504136
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 30 Apr 2021 to the primary completion date, 15 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving steroid therapy or metformin
Other illness
- History of bleeding diathesis or coagulopathy
- Stroke or transient neurological attack with the last 6 months
- HIV positive
- History of total proctocolectomy
- History of system chemotherapy within 18 months
- Uncontrolled intercurrent illness
Lab values
- Receiving anticoagulants or anti-platelet medications other than low-dose aspirin
Other
- Classified in an anesthesia risk group, ASA Class =4
- Pregnant
- Incarceration
Who the study is looking for
- Diagnosed ulcerative colitis or Crohn's disease
- Biologic failure or naive to biologic treatment
- Eligible to be treated with anti-TNF therapy
- Diagnosed rheumatoid or psoriatic arthritis
- Receiving anti-TNF antibody therapy at the time of enrollment
- Endoscopically unremarkable colonic mucosa
- Absence of inflammatory bowel disease
Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Kentucky Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.